Author:

Keywords:

Science & Technology, Physical Sciences, Optics, DIFFUSE-REFLECTANCE, TURBID MEDIA, NONINVASIVE DETERMINATION, INVERSE MODEL, TISSUE, LIGHT, SPECTROSCOPY, COEFFICIENTS, PROPAGATION, SCATTERING, C16/16/002#53766054, 0205 Optical Physics, 0906 Electrical and Electronic Engineering, 1005 Communications Technologies, 4006 Communications engineering, 4009 Electronics, sensors and digital hardware, 5102 Atomic, molecular and optical physics

Abstract:

Non-invasive determination of the optical properties is essential for understanding the light propagation in biological tissues and developing optical techniques for quality detection. Simulation-based models provide flexibility in designing the search space, while measurement-based models can incorporate the unknown system responses. However, the interoperability between these two types of models is typically poor. In this research, the mismatches between measurements and simulations were explored by studying the influences from light source and the incident and detection angle on the diffuse reflectance profiles. After reducing the mismatches caused by the factors mentioned above, the simulated diffuse reflectance profiles matched well with the measurements, with R2 values above 0.99. Successively, metamodels linking the optical properties with the diffuse reflectance profiles were respectively built based on the measured and simulated profiles. The prediction performance of these metamodels was comparable, both obtaining R2 values above 0.96. Proper correction for these sources of mismatches between measurements and simulations thus allows to build a simulation-based metamodel with a wide range of desired optical properties that is applicable to different measurement configurations.