Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Guix, Francesc; Sannerud, Ragna; Berditchevski, Fedor; Arranz Mendiguren, Amaia; Horré, Katrien; Snellinx, An; Thathiah, Amantha; Saido, Takaomi; Saito, Takashi; Rajesh, Sundaresan; Overduin, Michael; Kumar-Singh, Samir; Radaelli, Enrico; Corthout, Nikky; Colombelli, Julien; Tosi, Sébastien; Munck, Sebastian; Salas Hernández, Isabel; Annaert, Wim; De Strooper, Bart

doi:10.1186/s13024-017-0165-0

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Author:

Guix, Francesc

Sannerud, Ragna ; Berditchevski, Fedor ; Arranz Mendiguren, Amaia ; Horré, Katrien ; Snellinx, An ; Thathiah, Amantha ; Saido, Takaomi ; Saito, Takashi ; Rajesh, Sundaresan ; Overduin, Michael ; Kumar-Singh, Samir ; Radaelli, Enrico ; Corthout, Nikky ; Colombelli, Julien ; Tosi, Sébastien ; Munck, Sebastian ; Salas Hernández, Isabel ; Annaert, Wim ; De Strooper, Bart

Keywords:

Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Alzheimer's disease, Amyloid precursor protein, Intraluminal vesicles, Multivesicular bodies, Tetraspanin-6, FAMILIAL ALZHEIMERS-DISEASE, GAMMA-SECRETASE, ENRICHED MICRODOMAINS, BETA-SECRETASE, MOUSE MODELS, INHIBITION, SYNTENIN, APP, PROTEOLYSIS, DYSFUNCTION, Alzheimer’s disease, Alzheimer Disease, Amyloid beta-Protein Precursor, Animals, Blotting, Western, Exosomes, Humans, Imaging, Three-Dimensional, Immunohistochemistry, Lysosomes, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Confocal, Neurons, Real-Time Polymerase Chain Reaction, Tetraspanins, 0604 Genetics, 1103 Clinical Sciences, 1109 Neurosciences, Neurology & Neurosurgery, 3101 Biochemistry and cell biology, 3209 Neurosciences

Abstract:

The mechanisms behind Aβ-peptide accumulation in non-familial Alzheimer's disease (AD) remain elusive. Proteins of the tetraspanin family modulate Aβ production by interacting to γ-secretase.