Molecular Neurodegeneration
Author:
Keywords:
Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Alzheimer's disease, Amyloid precursor protein, Intraluminal vesicles, Multivesicular bodies, Tetraspanin-6, FAMILIAL ALZHEIMERS-DISEASE, GAMMA-SECRETASE, ENRICHED MICRODOMAINS, BETA-SECRETASE, MOUSE MODELS, INHIBITION, SYNTENIN, APP, PROTEOLYSIS, DYSFUNCTION, Alzheimer’s disease, Alzheimer Disease, Amyloid beta-Protein Precursor, Animals, Blotting, Western, Exosomes, Humans, Imaging, Three-Dimensional, Immunohistochemistry, Lysosomes, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Confocal, Neurons, Real-Time Polymerase Chain Reaction, Tetraspanins, 0604 Genetics, 1103 Clinical Sciences, 1109 Neurosciences, Neurology & Neurosurgery, 3101 Biochemistry and cell biology, 3209 Neurosciences
Abstract:
The mechanisms behind Aβ-peptide accumulation in non-familial Alzheimer's disease (AD) remain elusive. Proteins of the tetraspanin family modulate Aβ production by interacting to γ-secretase.