Biological Psychiatry
Author:
Keywords:
Science & Technology, Life Sciences & Biomedicine, Neurosciences, Psychiatry, Neurosciences & Neurology, Endophenotype, genome-wide, imaging, psychiatric, SNPs, structural MRI, IN-VIVO, ASSOCIATION, SUSCEPTIBILITY, ABNORMALITIES, HERITABILITY, RELATIVES, TWINS, Adult, Atrophy, Brain, Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Nerve Fibers, Myelinated, Phenotype, Polymorphism, Single Nucleotide, Schizophrenia, Psychiatric Genome-wide Association Study Consortium, 06 Biological Sciences, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences, 31 Biological sciences, 32 Biomedical and clinical sciences, 52 Psychology
Abstract:
Thousands of common single nucleotide polymorphisms (SNPs) are weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs are associated with distinct heritable disease-associated phenotypes. Therefore, we examined the shared genetic susceptibility modulating schizophrenia and brain volume.