Genetic schizophrenia risk variants jointly modulate total brain and white matter volume
Terwisscha van Scheltinga, Afke F × Bakker, Steven C van Haren, Neeltje E M Derks, Eske M Buizer-Voskamp, Jacobine E Boos, Heleen B M Cahn, Wiepke Hulshoff Pol, Hilleke E Ripke, Stephan Ophoff, Roel A Kahn, René S Psychiatric Genome-wide Association Study Consortium De Hert, Marc #
Thousands of common single nucleotide polymorphisms (SNPs) are weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs are associated with distinct heritable disease-associated phenotypes. Therefore, we examined the shared genetic susceptibility modulating schizophrenia and brain volume.