Genetic schizophrenia risk variants jointly modulate total brain and white matter volume

Terwisscha van Scheltinga, Afke F; Bakker, Steven C; van Haren, Neeltje EM; Derks, Eske M; Buizer-Voskamp, Jacobine E; Boos, Heleen BM; Cahn, Wiepke; Hulshoff Pol, Hilleke E; Ripke, Stephan; Ophoff, Roel A; Kahn, René S; Psychiatric Genome-wide Association Study Consortium,; Myin-Germeys, Inez; De Hert, Marc; van Winkel, Ruud

doi:10.1016/j.biopsych.2012.08.017

Genetic schizophrenia risk variants jointly modulate total brain and white matter volume

Author:

Terwisscha van Scheltinga, Afke F

Bakker, Steven C ; van Haren, Neeltje EM ; Derks, Eske M ; Buizer-Voskamp, Jacobine E ; Boos, Heleen BM ; Cahn, Wiepke ; Hulshoff Pol, Hilleke E ; Ripke, Stephan ; Ophoff, Roel A ; Kahn, René S ; Psychiatric Genome-wide Association Study Consortium, ; Myin-Germeys, Inez ; De Hert, Marc ; van Winkel, Ruud

Keywords:

Science & Technology, Life Sciences & Biomedicine, Neurosciences, Psychiatry, Neurosciences & Neurology, Endophenotype, genome-wide, imaging, psychiatric, SNPs, structural MRI, IN-VIVO, ASSOCIATION, SUSCEPTIBILITY, ABNORMALITIES, HERITABILITY, RELATIVES, TWINS, Adult, Atrophy, Brain, Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Nerve Fibers, Myelinated, Phenotype, Polymorphism, Single Nucleotide, Schizophrenia, Psychiatric Genome-wide Association Study Consortium, 06 Biological Sciences, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences, 31 Biological sciences, 32 Biomedical and clinical sciences, 52 Psychology

Abstract:

Thousands of common single nucleotide polymorphisms (SNPs) are weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs are associated with distinct heritable disease-associated phenotypes. Therefore, we examined the shared genetic susceptibility modulating schizophrenia and brain volume.