Mixed oligonucleotide analogs with an acyclic carbohydrate moiety and a N-cyanoguanidine functionality

Pannecouque, Christophe; Schepers, Guy; Rozenski, Jef; Van Aerschot, Arthur; Claes, Paul; Herdewijn, Piet

doi:10.1016/S0960-894X(01)80330-9

Mixed oligonucleotide analogs with an acyclic carbohydrate moiety and a N-cyanoguanidine functionality

Author:

Pannecouque, Christophe

Schepers, Guy ; Rozenski, Jef ; Van Aerschot, Arthur ; Claes, Paul ; Herdewijn, Piet

Keywords:

subunits, dimers, dna, Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Chemistry, Medicinal, Chemistry, Organic, Pharmacology & Pharmacy, Chemistry, SUBUNITS, DIMERS, DNA, 0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, 1115 Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, 3404 Medicinal and biomolecular chemistry, 3405 Organic chemistry

Abstract:

Mixed oligonucleotide analogues having a backbone structure with a N-cyanoguanidine functionality and an acyclic sugar moiety were synthesized This combination, however, has a detrimental effect on duplex stability of DNA-DNA hybrids.