Bioorganic & medicinal chemistry letters
Publication date:
1994-01-01
Pages:
1203 -
1206
Publisher:
Pergamon-elsevier science ltd
Author:
Pannecouque, Christophe
Schepers, Guy ; Rozenski, Jef ; Van Aerschot, Arthur ; Claes, Paul ; Herdewijn, Piet
Keywords:
subunits, dimers, dna, Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Chemistry, Medicinal, Chemistry, Organic, Pharmacology & Pharmacy, Chemistry, SUBUNITS, DIMERS, DNA, 0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, 1115 Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, 3404 Medicinal and biomolecular chemistry, 3405 Organic chemistry
Abstract:
Mixed oligonucleotide analogues having a backbone structure with a N-cyanoguanidine functionality and an acyclic sugar moiety were synthesized This combination, however, has a detrimental effect on duplex stability of DNA-DNA hybrids.