Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson's disease discerned with microSPECT and quantitative MRI

Van Camp, Nadja; Vreys, Ruth; Van Laere, Koen; Lauwers, Erwin; Beque, Dirk; Verhoye, Marleen; Casteels, Cindy; Verbruggen, Alfons; Debyser, Zeger; Mortelmans, Luc; Sijbers, Jan; Nuyts, Johan; Baekelandt, Veerle; Van der Linden, Annemie

doi:10.1007/s10334-010-0198-7

Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson's disease discerned with microSPECT and quantitative MRI

Author:

Van Camp, Nadja

Vreys, Ruth ; Van Laere, Koen ; Lauwers, Erwin ; Beque, Dirk ; Verhoye, Marleen ; Casteels, Cindy ; Verbruggen, Alfons ; Debyser, Zeger ; Mortelmans, Luc ; Sijbers, Jan ; Nuyts, Johan ; Baekelandt, Veerle ; Van der Linden, Annemie

Keywords:

Animals, Corpus Striatum, Disease Models, Animal, Female, Magnetic Resonance Imaging, Oxidopamine, Parkinsonian Disorders, Positron-Emission Tomography, Rats, Rats, Wistar, Reproducibility of Results, Sensitivity and Specificity, Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, Parkinson's disease, Rat, Neurodegeneration, SPECT, MRI, DOPAMINE TRANSPORTER, MAGNETIC-RESONANCE, IRON CONTENT, CAUDATE-PUTAMEN, ALPHA-SYNUCLEIN, PINHOLE SPECT, IN-VIVO, BRAIN, NEURONS, OVEREXPRESSION, Radiography, Nuclear Medicine & Medical Imaging

Abstract:

In the present study, we aimed to evaluate the impact of neurodegeneration of the nigrostriatal tract in a rodent model of Parkinson's disease on the different MR contrasts (T(2), T(1), CBF and CBV) measured in the striatum.