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Magnetic Resonance Materials in Biology, Physics and Medicine

Publication date: 2010-04-01
Volume: 23 Pages: 65 - 75
Publisher: Chapman & Hall

Author:

Van Camp, Nadja
Vreys, Ruth ; Van Laere, Koen ; Lauwers, Erwin ; Beque, Dirk ; Verhoye, Marleen ; Casteels, Cindy ; Verbruggen, Alfons ; Debyser, Zeger ; Mortelmans, Luc ; Sijbers, Jan ; Nuyts, Johan ; Baekelandt, Veerle ; Van der Linden, Annemie

Keywords:

Animals, Corpus Striatum, Disease Models, Animal, Female, Magnetic Resonance Imaging, Oxidopamine, Parkinsonian Disorders, Positron-Emission Tomography, Rats, Rats, Wistar, Reproducibility of Results, Sensitivity and Specificity, Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, Parkinson's disease, Rat, Neurodegeneration, SPECT, MRI, DOPAMINE TRANSPORTER, MAGNETIC-RESONANCE, IRON CONTENT, CAUDATE-PUTAMEN, ALPHA-SYNUCLEIN, PINHOLE SPECT, IN-VIVO, BRAIN, NEURONS, OVEREXPRESSION, Radiography, Nuclear Medicine & Medical Imaging

Abstract:

In the present study, we aimed to evaluate the impact of neurodegeneration of the nigrostriatal tract in a rodent model of Parkinson's disease on the different MR contrasts (T(2), T(1), CBF and CBV) measured in the striatum.