Transplantation Proceedings
Author:
Keywords:
Science & Technology, Life Sciences & Biomedicine, Immunology, Surgery, Transplantation, CARDIAC DEATH DONORS, HEART-BEATING DONORS, RAT-LIVER, PRESERVATION SOLUTION, GRAFT-SURVIVAL, DONATION, POLYSOL, Animals, Feasibility Studies, Graft Survival, Hypothermia, Induced, Liver, Liver Transplantation, Models, Animal, Organ Preservation, Organ Preservation Solutions, Perfusion, Portal Vein, Swine, 11 Medical and Health Sciences, 3202 Clinical sciences, 3204 Immunology
Abstract:
Objective. Hypothermic machine perfusion (HMP) is superior to simple cold storage for kidney preservation, We previous observed in a porcine liver transplantation model increased tumor necrosis factor-alpha (TNF-alpha) production eventually leading to poor recipient survival after HMP using standard kidney perfusion solution (KPS-1) compared with simple cold storage. We compared two solutions for HMP preservation of the liver: enriched KPS-1 (EKPS-1) and Aqix RS-I.