Hypothermic liver machine perfusion with a modified KPS-1 solution vs. AQIX RS-I solution : an in vivo feasibility study in a pig transplant model

Vekemans, Katrien; Liu, Qiang; Heedfeld, V; Van de Vel, K; Pirenne, Jacques; Monbaliu, Diethard

doi:10.1016/j.transproceed.2008.12.022

Hypothermic liver machine perfusion with a modified KPS-1 solution vs. AQIX RS-I solution : an in vivo feasibility study in a pig transplant model

Author:

Vekemans, Katrien

Liu, Qiang ; Heedfeld, V ; Van de Vel, K ; Pirenne, Jacques ; Monbaliu, Diethard

Keywords:

Science & Technology, Life Sciences & Biomedicine, Immunology, Surgery, Transplantation, CARDIAC DEATH DONORS, HEART-BEATING DONORS, RAT-LIVER, PRESERVATION SOLUTION, GRAFT-SURVIVAL, DONATION, POLYSOL, Animals, Feasibility Studies, Graft Survival, Hypothermia, Induced, Liver, Liver Transplantation, Models, Animal, Organ Preservation, Organ Preservation Solutions, Perfusion, Portal Vein, Swine, 11 Medical and Health Sciences, 3202 Clinical sciences, 3204 Immunology

Abstract:

Objective. Hypothermic machine perfusion (HMP) is superior to simple cold storage for kidney preservation, We previous observed in a porcine liver transplantation model increased tumor necrosis factor-alpha (TNF-alpha) production eventually leading to poor recipient survival after HMP using standard kidney perfusion solution (KPS-1) compared with simple cold storage. We compared two solutions for HMP preservation of the liver: enriched KPS-1 (EKPS-1) and Aqix RS-I.