Title: Pannexins, distant relatives of the connexin family with specific cellular functions?
Authors: D'hondt, Catheleyne ×
Ponsaerts, Raf
De Smedt, Humbert
Bultynck, Geert
Himpens, Bernard #
Issue Date: Jul-2009
Publisher: Co. of Biologists
Series Title: BioEssays vol:31 issue:9 pages:953-974
Abstract: Intercellular communication (IC) is mediated by gap junctions (GJs) and hemichannels, which consist of proteins. This has been particularly well documented for the connexin (Cx) family. Initially, Cxs were thought to be the only proteins capable of GJ formation in vertebrates. About 10 years ago, however, a new GJ-forming protein family related to invertebrate innexins (Inxs) was discovered in vertebrates, and named the pannexin (Panx) family. Panxs, which are structurally similar to Cxs, but evolutionarily distinct, have been shown to be co-expressed with Cxs in vertebrates. Both protein families show distinct properties and have their own particular function. Identification of the mechanisms that control Panx channel gating is a major challenge for future work. In this review, we focus on the specific properties and role of Panxs in normal and pathological conditions.
ISSN: 0265-9247
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular and Cellular Signaling
× corresponding author
# (joint) last author

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2009 Review Catheleyne Biosessays BIES200800236.pdf Published 1071KbAdobe PDFView/Open
BioEssays2009.pdfDhondt_BioEssays_2009 Published 753KbAdobe PDFView/Open


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