Title: Single nucleotide polymorphism analysis of corticotropinreleasing factor-binding protein gene in bipolar disorder
Authors: Van den Eede, Filip ×
Venken, Tine
Van den Bogaert, Ann
Del-Favero, Jurgen
Norrback, Karl-Fredrik
Nilsson, Lars Goran
Adolfsson, Rolf
Van Broeckhoven, Christine
Claes, Stephan #
Issue Date: Oct-2007
Publisher: Lippincott williams & wilkins
Series Title: Psychiatric genetics vol:17 issue:5 pages:304-307
Abstract: Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. The aim of this study was to examine the association between polymorphisms in CRF-BP gene and bipolar disorder in an isolated Swedish population. One hundred and eighty-two patients with bipolar I disorder and 333 controls from Northern Sweden were included in the study. Five single nucleotide polymorphisms and a deletion polymorphism in the CRF-BP gene were genotyped. The haplotype block structure of the gene was considered and the expectation maximization algorithm was adopted to estimate the haplotype frequencies. As a result, there were no significant associations of the different polymorphisms in the CRF-BP gene with bipolar disorder. In conclusion, this study in an isolated Swedish population does not support a role for the CRF-BP gene in the vulnerability for bipolar disorder.
ISSN: 0955-8829
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Psychiatry
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science