Author:

Keywords:

bipolar disorder, corticotropin-releasing factor-binding protein, genetics, hypothalamic-pituitary-adrenal axis, vulnerability, pituitary-adrenal axis, major depression, hormone test, population, unipolar, cortisol, crf, Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, Neurosciences, Neurosciences & Neurology, PITUITARY-ADRENAL AXIS, DEPRESSION, POPULATION, UNIPOLAR, CORTISOL, CRF, Algorithms, Bipolar Disorder, Carrier Proteins, Genotype, Humans, Polymorphism, Single Nucleotide, Reference Values, Sweden, 0604 Genetics, 1103 Clinical Sciences, 1109 Neurosciences, Psychiatry, 3105 Genetics, 3202 Clinical sciences, 3209 Neurosciences

Abstract:

Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. The aim of this study was to examine the association between polymorphisms in CRF-BP gene and bipolar disorder in an isolated Swedish population. One hundred and eighty-two patients with bipolar I disorder and 333 controls from Northern Sweden were included in the study. Five single nucleotide polymorphisms and a deletion polymorphism in the CRF-BP gene were genotyped. The haplotype block structure of the gene was considered and the expectation maximization algorithm was adopted to estimate the haplotype frequencies. As a result, there were no significant associations of the different polymorphisms in the CRF-BP gene with bipolar disorder. In conclusion, this study in an isolated Swedish population does not support a role for the CRF-BP gene in the vulnerability for bipolar disorder.