Impaired cerebral autoregulation using Near-Infrared Spectroscopy and its relation to clinical outcomes in premature infants

Caicedo Dorado, Alexander; De Smet, Dominique; Vanderhaegen, Joke; Naulaers, Gunnar; Wolf, Martin; Lemmers, Petra; Van Bel, Frank; Ameye, Lieveke; Van Huffel, Sabine

doi:10.1007/978-1-4419-7756-4_31

Impaired cerebral autoregulation using Near-Infrared Spectroscopy and its relation to clinical outcomes in premature infants

Author:

Caicedo Dorado, Alexander

De Smet, Dominique ; Vanderhaegen, Joke ; Naulaers, Gunnar ; Wolf, Martin ; Lemmers, Petra ; Van Bel, Frank ; Ameye, Lieveke ; Van Huffel, Sabine

Keywords:

blood-flow, oxygenation, pressure, babies, SISTA, Science & Technology, Life Sciences & Biomedicine, Biology, Medicine, Research & Experimental, Physiology, Life Sciences & Biomedicine - Other Topics, Research & Experimental Medicine, BLOOD-FLOW, OXYGENATION, PRESSURE, Blood Pressure, Brain, Cerebrovascular Circulation, Homeostasis, Humans, Infant, Newborn, Infant, Premature, Oximetry, Oxygen, Spectroscopy, Near-Infrared, Treatment Outcome, 11 Medical and Health Sciences, General & Internal Medicine, 31 Biological sciences, 32 Biomedical and clinical sciences

Abstract:

The concordance between the change in the Mean Arterial Blood Pressure (MABP) and the Cerebral Blood Flow (CBF) is studied using the Correlation, Coherence and Partial Coherence methods in order to detect Impaired Cerebral Autoregulation in Neonates. The presence of impaired autoregulation is assessed by the use of the Critical Percentage of Recording Time (CPRT). The changes in CBF are reflected by the measurement of changes in cerebral intravascular oxygenation (HbD), regional cerebral oxygen saturation (rSO(2)), and cerebral tissue oxygenation (TOI), as measured by Near-Infrared Spectroscopy (NIRS) (INVOS4100 and NIRO300). The relation between impaired autoregulation and long term clinical outcomes in premature infants is studied.