Prognostic Value of Serologic and Histologic Markers on Clinical Relapse in Ulcerative Colitis Patients With Mucosal Healing

Bessissow, Talat; Bessissow, Talat; Lemmens, Bart; Ferrante, Marc; Bisschops, Raf; Van Steen, Kristel; Geboes, Karel; Van Assche, Gert; Vermeire, Séverine; Rutgeerts, Paul; De Hertogh, Gert

doi:10.1038/ajg.2012.301

Prognostic Value of Serologic and Histologic Markers on Clinical Relapse in Ulcerative Colitis Patients With Mucosal Healing

Author:

Bessissow, Talat

Bessissow, Talat ; Lemmens, Bart ; Ferrante, Marc ; Bisschops, Raf ; Van Steen, Kristel ; Geboes, Karel ; Van Assche, Gert ; Vermeire, Séverine ; Rutgeerts, Paul ; De Hertogh, Gert

Keywords:

Adult, Biomarkers, Biopsy, Chi-Square Distribution, Colitis, Ulcerative, Endoscopy, Gastrointestinal, Female, Humans, Intestinal Mucosa, Logistic Models, Male, Middle Aged, Predictive Value of Tests, Prognosis, Recurrence, Retrospective Studies, Statistics, Nonparametric, Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, INFLAMMATORY-BOWEL-DISEASE, CROHNS-DISEASE, INFLIXIMAB, THERAPY, PARAMETERS, 1103 Clinical Sciences, 3202 Clinical sciences

Abstract:

Endoscopic mucosal healing is a key endpoint for the treatment of ulcerative colitis (UC). The role of microscopic activity in predicting disease relapse has not been fully assessed. We aimed to investigate the predictive role of serologic and histologic markers on disease relapse in UC patients with endoscopically inactive disease.