Chromosome aberrations in fibrous dysplasia

Dal Cin, Paola; Sciot, Raphael; Speleman, F; Samson, Ignace; Laureys, G; de Potter, C; Meire, F; Van Damme, Boudewijn; Van den Berghe, Herman

doi:10.1016/0165-4608(94)90225-9

Chromosome aberrations in fibrous dysplasia

Author:

Dal Cin, Paola

Sciot, Raphael ; Speleman, F ; Samson, Ignace ; Laureys, G ; de Potter, C ; Meire, F ; Van Damme, Boudewijn ; Van den Berghe, Herman

Keywords:

Adult, Child, Chromosome Aberrations, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 2, Chromosomes, Human, Pair 6, Female, Fibrous Dysplasia of Bone, Humans, Karyotyping, Science & Technology, Life Sciences & Biomedicine, Oncology, Genetics & Heredity, TUMORS, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, 3105 Genetics, 3211 Oncology and carcinogenesis

Abstract:

We report the cytogenetic findings of two cases of fibrous dysplasia, one occurring in the tibia, the other in the sphenoid. Both cases exhibited only one chromosome change: a t(6;11)(q15;p15) in the first case, a derivative chromosome 2 in the second. The previous cytogenetic report on fibrous dysplasia revealed only numerical changes. The significance of these inconsistent chromosomal findings in fibrous dysplasia is unclear.