Author:

Keywords:

red blood cell, Erythrocytes, atomic force microscope, Humans, Research Support, Non-U.S. Gov't, scanning electron microscope, Science & Technology, Life Sciences & Biomedicine, Hematology, Microscopy, Atomic Force, 1102 Cardiorespiratory Medicine and Haematology, Immunology, 3201 Cardiovascular medicine and haematology

Abstract:

A novel technique for the reproduction of ultramorphological images and details of the surface of normal and pathological red blood cells (RBC) was investigated. The atomic force microscope (AFM) provided high-resolution images of cell surfaces. The RBC dimensions obtained by this technique revealed differences between native red cells in smears and glutaraldehyde-fixed red cells. It was shown that fixed red blood cells were best suited for the ultramorphological imaging of the cell surface.