Author:

Keywords:

Enterovirus, antivirals, early stage, pirodavir, pleconaril, Antiviral Agents, Dose-Response Relationship, Drug, Microbial Sensitivity Tests, Oxadiazoles, Oxazoles, Piperidines, Pyridazines, Structure-Activity Relationship, 0304 Medicinal and Biomolecular Chemistry, 0601 Biochemistry and Cell Biology, 1117 Public Health and Health Services, Virology, 3404 Medicinal and biomolecular chemistry

Abstract:

The Enterovirus genus of the Picornaviridae is represented by several viral pathogens that are associated with human disease, namely Poliovirus 1, Enterovirus 71 and Rhinoviruses. Enterovirus 71 has been associated with encephalitis, while Rhinoviruses are a major cause of asthma exacerbations and chronic obstructive pulmonary disease. Based on the structure of both pleconaril and pirodavir, we previously synthesized some original compounds as potential inhibitors of Rhinovirus replication.