Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, Gastric Barostat, Therapy, Clinical Trial, Mechanoreceptor, GASTRIC SENSORIMOTOR FUNCTION, ACID BREATH TEST, GASTRODUODENAL DISORDERS, MYENTERIC NEURONS, CONTROLLED-TRIAL, NITRIC-OXIDE, SYMPTOMS, ACCOMMODATION, AGONIST, HYPERSENSITIVITY, Adult, Aged, Buspirone, Cross-Over Studies, Double-Blind Method, Dyspepsia, Female, Gastric Emptying, Gastrointestinal Agents, Humans, Male, Middle Aged, Placebos, Treatment Outcome, 1103 Clinical Sciences, 3202 Clinical sciences

Abstract:

Impaired accommodation and hypersensitivity to gastric distention are believed to be involved in the development of functional dyspepsia (FD). Buspirone, a 5-hydroxytryptamine 1A receptor agonist, relaxes the proximal stomach in healthy individuals. We studied the effects of buspirone on symptoms and mechanisms of FD.