The Release of MicroRNA-122 During Liver Preservation is Associated with Early Allograft Dysfunction and Graft Survival After Transplantation

Selten, Jasmijn W; Verhoeven, Cornelia J; Heedfeld, Veerle; Roest, Henk P; de Jonge, Jeroen; Pirenne, Jacques; van Pelt, Jos; IJzermans, Jan NM; Monbaliu, Diethard; van der Laan, Luc JW

doi:10.1002/lt.24766

The Release of MicroRNA-122 During Liver Preservation is Associated with Early Allograft Dysfunction and Graft Survival After Transplantation

Author:

Selten, Jasmijn W

Verhoeven, Cornelia J ; Heedfeld, Veerle ; Roest, Henk P ; de Jonge, Jeroen ; Pirenne, Jacques ; van Pelt, Jos ; IJzermans, Jan NM ; Monbaliu, Diethard ; van der Laan, Luc JW

Keywords:

Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, Surgery, Transplantation, SOLID-ORGAN TRANSPLANTATION, EXTENDED-DONOR CRITERIA, MACHINE PERFUSION, CIRCULATING MICRORNAS, POTENTIAL BIOMARKER, HEPATITIS-C, SERUM, INJURY, EXPRESSION, MIR-122, Adult, Aged, Allografts, Animals, Female, Graft Survival, Humans, Liver Transplantation, Male, MicroRNAs, Middle Aged, Organ Preservation, Swine, 1103 Clinical Sciences, 3202 Clinical sciences

Abstract:

Early allograft dysfunction (EAD) after liver transplantation is associated with inferior graft survival. EAD is more prevalent in grafts from donation after circulatory death (DCD). However, accurate prediction of liver function remains difficult due to the lack of specific biomarkers. Recent experimental and clinical studies highlight the potential of hepatocyte-derived microRNAs (miRNAs) as sensitive, stable and specific biomarkers of liver injury. The aim of this study was to determine whether miRNAs in graft preservation fluid are predictive for EAD after clinical liver transplantation and in an experimental DCD model.