Author:

Keywords:

Adenine, replication in-vitro, Antiviral Agents, acyclic nucleoside phosphonates, Cells, Cultured, poxvirus infections, alkoxyalkyl esters, Cyclization, Cytopathogenic Effect, Viral, virus-infections, Cytosine, raft cultures, Esters, smallpox, Fibroblasts, efficacy, vaccinia, Humans, analogs, Keratinocytes, Orthopoxvirus, Phosphonic Acids, Science & Technology, Life Sciences & Biomedicine, Microbiology, Pharmacology & Pharmacy, REPLICATION IN-VITRO, ACYCLIC NUCLEOSIDE PHOSPHONATES, POXVIRUS INFECTIONS, ALKOXYALKYL ESTERS, VIRUS-INFECTIONS, RAFT CULTURES, SMALLPOX, EFFICACY, VACCINIA, ANALOGS, Cidofovir, Organophosphonates, 0605 Microbiology, 1108 Medical Microbiology, 1115 Pharmacology and Pharmaceutical Sciences, 3107 Microbiology, 3207 Medical microbiology, 3214 Pharmacology and pharmaceutical sciences

Abstract:

The potencies of several alkoxyalkyl esters of acyclic nucleoside phosphonates against vaccinia virus and cowpox virus were evaluated in cell monolayers and three-dimensional epithelial raft cultures. Prodrugs were at least 20-fold more active than their parent compounds. Octadecycloxyethyl-(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine emerged as the most potent derivative.