Ibuprofen and cerebral oxygenation and circulation

Naulaers, Gunnar; Delanghe, G; Allegaert, Karel; Debeer, A; Cossey, V; Vanhole, Christine; Casaer, Paul; Devlieger, Hugo; Van Overmeire, B

doi:10.1136/adc.2004.058347

Ibuprofen and cerebral oxygenation and circulation

Author:

Naulaers, Gunnar

Delanghe, G ; Allegaert, Karel ; Debeer, A ; Cossey, V ; Vanhole, Christine ; Casaer, Paul ; Devlieger, Hugo ; Van Overmeire, B

Keywords:

controlled-trial, preterm infants, blood-volume, Science & Technology, Life Sciences & Biomedicine, Pediatrics, CONTROLLED-TRIAL, BLOOD-VOLUME, PRETERM, Anti-Inflammatory Agents, Non-Steroidal, Brain, Cerebrovascular Circulation, Double-Blind Method, Humans, Ibuprofen, Infant, Newborn, Infant, Premature, Oxygen, Oxygen Consumption, Prospective Studies, Spectroscopy, Near-Infrared, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 1117 Public Health and Health Services, 3202 Clinical sciences, 3213 Paediatrics

Abstract:

The effect of prophylactic administration of ibuprofen on the cerebral circulation in preterm babies was measured with near infrared spectroscopy. No significant difference in the change in cerebral blood volume, change in cerebral blood flow, or tissue oxygenation index was found between administration of ibuprofen or placebo.