Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Obstetrics & Gynecology, Reproductive Biology, JNK, endometriosis, baboons, endometriotic lesions, biomarkers, PERITONEAL ENDOMETRIOSIS, PROGESTERONE RESISTANCE, AROMATASE INHIBITOR, JNK INHIBITOR, PROGRESSION, MODEL, PAIN, EXPRESSION, REGRESSION, DISEASE, Animals, Benzothiazoles, Disease Models, Animal, Drug Therapy, Combination, Endometriosis, Endometrium, Female, Gonadotropin-Releasing Hormone, Hormones, JNK Mitogen-Activated Protein Kinases, Laparoscopy, Medroxyprogesterone Acetate, Menstrual Cycle, Papio anubis, Protein Kinase Inhibitors, Pyrimidines, Random Allocation, Signal Transduction, Time Factors, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 1117 Public Health and Health Services, Obstetrics & Reproductive Medicine, 3215 Reproductive medicine

Abstract:

To test the hypothesis that the c-Jun NH2-terminal kinase (JNK) inhibitor (JNKI) bentamapimod (AS602801/PGL5001) can reduce induced endometriosis in baboons.