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Annals of Oncology

Publication date: 2014-01-01
Volume: 25 Pages: 1995 - 2001
Publisher: Kluwer Academic Publishers

Author:

Missiaglia, E
Jacobs, Bart ; D'Ario, G ; Di Narzo, AF ; Soneson, C ; Budinska, E ; Popovici, V ; Vecchione, Loredana ; Gerster, S ; Yan, Pengcheng ; Roth, AD ; Klingbiel, D ; Bosman, FT ; Delorenzi, M ; Tejpar, Sabine

Keywords:

colon cancer, expression profiling, mutations, oncogenic pathways, survival, Science & Technology, Life Sciences & Biomedicine, Oncology, COLORECTAL-CANCER, EXPRESSION, STAGE, CLASSIFICATION, EPIDEMIOLOGY, SURVIVAL, TRIAL, Colonic Neoplasms, DNA Copy Number Variations, Disease-Free Survival, Female, Gene Expression Regulation, Neoplastic, Humans, Male, Microsatellite Instability, Neoplasm Metastasis, Neoplasm Proteins, Neoplasm Recurrence, Local, Neoplasm Staging, Prognosis, Proto-Oncogene Mas, Translational Research, Biomedical, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, 3202 Clinical sciences, 3211 Oncology and carcinogenesis

Abstract:

Differences exist between the proximal and distal colon in terms of developmental origin, exposure to patterning genes, environmental mutagens, and gut flora. Little is known on how these differences may affect mechanisms of tumorigenesis, side-specific therapy response or prognosis. We explored systematic differences in pathway activation and their clinical implications.