Author:

Keywords:

sturge-weber syndrome, fdg pet, cerebral cortical metabolism, epilepsy, accelerated myelination, tomography, Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, Sturge-Weber syndrome, FDG PET, ACCELERATED MYELINATION, TOMOGRAPHY, Cerebral Cortex, Fluorodeoxyglucose F18, Humans, Infant, Positron-Emission Tomography, Sturge-Weber Syndrome, 1103 Clinical Sciences, Nuclear Medicine & Medical Imaging, 3202 Clinical sciences

Abstract:

Sturge-Weber syndrome (SWS) is a congenital, noninherited neurocutaneous syndrome, characterized by angiomas located in the facial skin and leptomeninges and often associated with severe epilepsy. We report a paradoxical finding on FDG PET with interictally increased metabolism in the affected hemisphere and contralateral cerebellum in an infant with epilepsy due to SWS. PET imaging was performed to assess the extent and degree of cerebral metabolic impairment before epilepsy surgery. Although the exact mechanism underlying this paradoxical hypermetabolism remains unclear, it may play an important role in the pathophysiologic progression of SWS.