Histamine Receptor H1-mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

Wouters, Mira; Balemans, Dafne; van Wanrooy, Sander; Dooley, James; Cibert-Goton, Vincent; Aguiar Alpizar, Yeranddy; Valdez-Morales, Eduardo E; Nasser, Yasmin; Van Veldhoven, Paul P; Vanbrabant, Winde; Van der Merwe, Schalk; Mols, Raf; Ghesquière, Bart; Cirillo, Carla; Kortekaas, Inge; Carmeliet, Peter; Peetermans, Willy; Vermeire, Séverine; Rutgeerts, Paul; Augustijns, Patrick; Hellings, Peter; Belmans, Ann; Vanner, Stephen; Bulmer, David C; Talavera Pérez, Karel; Vanden Berghe, Pieter; Liston, Adrian; Boeckxstaens, Guy

doi:10.1053/j.gastro.2015.12.034

Histamine Receptor H1-mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

Author:

Wouters, Mira

Balemans, Dafne ; van Wanrooy, Sander ; Dooley, James ; Cibert-Goton, Vincent ; Aguiar Alpizar, Yeranddy ; Valdez-Morales, Eduardo E ; Nasser, Yasmin ; Van Veldhoven, Paul P ; Vanbrabant, Winde ; Van der Merwe, Schalk ; Mols, Raf ; Ghesquière, Bart ; Cirillo, Carla ; Kortekaas, Inge ; Carmeliet, Peter ; Peetermans, Willy ; Vermeire, Séverine ; Rutgeerts, Paul ; Augustijns, Patrick ; Hellings, Peter ; Belmans, Ann ; Vanner, Stephen ; Bulmer, David C ; Talavera Pérez, Karel ; Vanden Berghe, Pieter ; Liston, Adrian ; Boeckxstaens, Guy

Keywords:

Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, Sensory Neurons, Drug, Treatment, Transient Receptor Potential Cation Channel Subfamily V Member 1, PLACEBO-CONTROLLED TRIAL, POTENTIAL VANILLOID 1, PROTEIN-KINASE-C, BINDING-SITE, COLONIC HYPERSENSITIVITY, MUTATIONAL ANALYSIS, CLINICAL-TRIALS, ION CHANNELS, LINACLOTIDE, DISORDERS, Abdominal Pain, Adolescent, Adult, Aged, Analgesics, Belgium, Biopsy, Butyrophenones, Calcium Signaling, Double-Blind Method, Female, Gastrointestinal Agents, Histamine H1 Antagonists, Humans, Irritable Bowel Syndrome, Male, Middle Aged, Neurons, Pain Measurement, Pain Threshold, Piperidines, Quality of Life, Receptor Cross-Talk, Receptors, Histamine H1, Rectum, Remission Induction, Surveys and Questionnaires, TRPV Cation Channels, Time Factors, Treatment Outcome, Young Adult, 1103 Clinical Sciences, 1109 Neurosciences, 1114 Paediatrics and Reproductive Medicine, 3202 Clinical sciences, 3210 Nutrition and dietetics

Abstract:

Histamine sensitizes the nociceptor TRPV1 and has been shown to contribute to visceral hypersensitivity in animals. We investigated the role of TRPV1 in irritable bowel syndrome (IBS) and evaluated if an antagonist of histamine receptor H1 (HRH1) could reduce symptoms of patients in a randomized placebo controlled trial.