Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Anesthesiology, Paediatric anaesthesia, Obstetric anaesthesia, Foetal surgery, Anaesthesia -induced neurotoxicity, LARYNGEAL MASK AIRWAY, NON-OBSTETRIC SURGERY, INFERIOR VENA-CAVA, CRICOID PRESSURE, GENERAL-ANESTHESIA, CESAREAN DELIVERY, INDUCED APOPTOSIS, PREGNANT PATIENTS, STOMACH CONTENTS, TRANSFUSION, Anaesthesia-induced neurotoxicity, Humans, Pregnancy, Female, Anesthesia, Fetus, Animals, Ultrasonography, Prenatal, Fetal Diseases, 1103 Clinical Sciences, 3202 Clinical sciences

Abstract:

Nowadays, widespread antenatal ultrasound screenings detect congenital anomalies earlier and more frequently. This has sparked research into foetal surgery, offering treatment options for various conditions. These surgeries aim to correct anomalies or halt disease progression until after birth. Minimally invasive procedures can be conducted under local anaesthesia (with/without maternal sedation), while open mid-gestational procedures necessitate general anaesthesia. Anaesthesia serves to prevent maternal and foetal pain, to provide immobilization, and to optimize surgical conditions by ensuring uterine relaxation. As early as 12 weeks after conception, the foetus may experience pain. Thus, in procedures involving innervated foetal tissue or requiring foetal immobilization, anaesthetic drugs can be administered directly to the foetus (intramuscular or intravenous) or indirectly (transplacental) to the mother. However, animal studies have indicated that exposure to prenatal anaesthesia might impact foetal brain development, translating these findings to the clinical setting remains difficult.