Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, Clinical Neurology, Neurosciences & Neurology, Diagnosis, Esophageal motility disorders, Gastroesophageal reflux, Manometry, Phenotype, ESOPHAGOGASTRIC JUNCTION CONTRACTILITY, INEFFECTIVE ESOPHAGEAL MOTILITY, MULTIPLE RAPID SWALLOWS, SOLID TEST MEAL, CHICAGO CLASSIFICATION, CLINICAL-ASSESSMENT, DIAGNOSTIC YIELD, BOLUS TRANSIT, ACID EXPOSURE, MANAGEMENT, 1101 Medical Biochemistry and Metabolomics, 1103 Clinical Sciences, 3202 Clinical sciences

Abstract:

Manometry, particularly high-resolution manometry is the preferred diagnostic tool used to evaluate esophageal motor function. This investigation is strongly indicated in the setting of dysphagia, but is also useful in gastroesophageal reflux disease (GERD), especially in case of failure of conventional treatment to exclude alternative diagnoses and prior to anti-reflux surgery. Moreover, ineffective esophagogastric junction barrier function and esophageal motor dysfunction are pathophysiological mechanisms in GERD and can be identified by manometry. The recent international guidelines have positioned high-resolution manometry as an important part of functional diagnostic work up in GERD in order to identify the GERD phenotype to guide specific treatment. The proposed manometric identification and measurement is based on the Chicago classification version 4.0 adding with new established metrics for GERD evaluation.