Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Nutrition & Dietetics, energy intake, erythritol, sucrose, sucralose, gastrointestinal satiation hormone, cholecystokinin, healthy participants, low-caloric sweeteners, GLUCAGON-LIKE PEPTIDE-1, ARTIFICIALLY SWEETENED BEVERAGES, SHORT-TERM CONSUMPTION, GLUCOSE-ABSORPTION, NONNUTRITIVE SWEETENER, GLP-1 SECRETION, SUCRALOSE, RELEASE, SUGAR, CHOLECYSTOKININ, Cholecystokinin, Cross-Over Studies, Energy Intake, Erythritol, Humans, Sucrose, Water, G0D2420N#55519329, 0908 Food Sciences, 1111 Nutrition and Dietetics, 3202 Clinical sciences, 3210 Nutrition and dietetics, 4206 Public health

Abstract:

The impact of oral erythritol on subsequent energy intake is unknown. The aim was to assess the effect of oral erythritol compared to sucrose, sucralose, or tap water on energy intake during a subsequent ad libitum test meal and to examine the release of cholecystokinin (CCK) in response to these substances. In this randomized, crossover trial, 20 healthy volunteers received 50 g erythritol, 33.5 g sucrose, or 0.0558 g sucralose dissolved in tap water, or tap water as an oral preload in four different sessions. Fifteen minutes later, a test meal was served and energy intake was assessed. At set time points, blood samples were collected to quantify CCK concentrations. The energy intake (ad libitum test meal) was significantly lower after erythritol compared to sucrose, sucralose, or tap water (p < 0.05). Before the start of the ad libitum test meal, erythritol led to a significant increase in CCK compared to sucrose, sucralose, or tap water (p < 0.001). Oral erythritol given alone induced the release of CCK before the start of the ad libitum test meal and reduced subsequent energy intake compared to sucrose, sucralose, or tap water. These properties make erythritol a useful sugar alternative.