Pleural decortication and hyperthermic intrathoracic chemotherapy for pseudomyxoma

Proesmans, Viktor; Vandaele, Tom; Van Slambrouck, Jan; Wolthuis, Albert; Hoore, Andre D; Dekervel, Jeroen; Van Cutsem, Eric; Dresen, Raphaela; De Hertogh, Gert; Degezelle, Karlien; Van Raemdonck, Dirk; Nafteux, Philippe; Ceulemans, Laurens J

doi:10.1080/02656736.2022.2104938

Pleural decortication and hyperthermic intrathoracic chemotherapy for pseudomyxoma

Author:

Proesmans, Viktor

Vandaele, Tom ; Van Slambrouck, Jan ; Wolthuis, Albert ; Hoore, Andre D ; Dekervel, Jeroen ; Van Cutsem, Eric ; Dresen, Raphaela ; De Hertogh, Gert ; Degezelle, Karlien ; Van Raemdonck, Dirk ; Nafteux, Philippe ; Ceulemans, Laurens J

Keywords:

COMPLETE RESECTION, CYTOREDUCTIVE SURGERY, HIPEC, HITHOC, INTRAPERITONEAL CHEMOTHERAPY, Life Sciences & Biomedicine, MANAGEMENT, METAANALYSIS, Oncology, OXALIPLATIN, PERITONEAL CARCINOMATOSIS, pleural decortication, pseudomyxoma peritonei, Radiology, Nuclear Medicine & Medical Imaging, Science & Technology, SURVIVAL, Aged, Appendiceal Neoplasms, Combined Modality Therapy, Cytoreduction Surgical Procedures, Humans, Hyperthermia, Induced, Male, Peritoneal Neoplasms, Pseudomyxoma Peritonei, Retrospective Studies, G090922N#56765308, 1103 Clinical Sciences, Oncology & Carcinogenesis, 3202 Clinical sciences

Abstract:

Aim: Pleural dissemination of pseudomyxoma peritonei (PMP) is an extremely rare diagnosis, for which no standard therapy is available.Methods: We describe the successful treatment of a 67-year-old male diagnosed with left-sided intrapleural dissemination of PMP (low-grade appendiceal mucinous neoplasm), 2 years after treatment of abdominal PMP with cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy. Treatment consisted of extended pleural decortication (ePD) and oxaliplatin-based hyperthermic intrathoracic chemotherapy (HITHOC). The patient is doing well without complications or signs of recurrence, 26 months after thoracic surgery.Conclusion: ePD in combination with HITHOC is a valuable treatment for thoracic PMP.