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Transplant Infectious Disease

Publication date: 2019-10-01
Volume: 21
Publisher: Wiley

Author:

Rammaert, Blandine
Puyade, Mathieu ; Cornely, Oliver A ; Seidel, Danila ; Grossi, Paolo ; Husain, Shahid ; Picard, Clement ; Lass-Floerl, Cornelia ; Manuel, Oriol ; Le Pavec, Jerome ; Lortholary, Olivier ; Nagel, Claudia ; Westall, Glen ; Morrissey, Orla ; Chambers, Daniel ; Eschertzhuber, Stephan ; Coussement, Julien ; ChristianeKnoop, ; Vos, Robin ; Dupont, Lieven ; Dumonceaux, Michel ; Campos, Silvia Vidal ; Kabbani, Dima ; Cervera, Carlos ; Me-Linh, Luong ; Blanchard, Elodie ; Senechal, Agathe ; Brugiere, Olivier ; Boussaud, Veronique ; Guillemain, Romain ; Bervar, Jean-Francois ; Claustre, Johanna ; Haloun, Alain ; Hirschi, Sandrine ; Reynaud, Martine ; Kneidinger, Nikolaus ; Gottlieb, Jens ; Roilides, Emmanuel ; Zarrinfar, Hossein ; Rosso, Lorenzo ; Morlacchi, Letizia Corinna ; Dell'Amore, Andrea ; Loy, Monica ; dos Santos, Claudy Oliveira ; JordiRello, ; Monforte, Victor ; Teresa Martin-Gomez, Maria ; Lopez Medrano, Francisco ; Fernandez-Ruiz, Mario ; Sole, Amparo ; Cifrian, Jose M ; Neofytos, Dionysios ; Mueller, Nicolas ; Benden, Christian ; Brill, Anne Kathrin ; Kiyan, Esen ; Gould, Kate ; Gkrania-Klotsas, Effrossyni ; David, Miruna ; Weigt, Sam ; Kwak, Eun Jeong ; Silveira, Femanda ; Hadjiliadis, Denis ; Baddley, John ; Danziger-Isakov, Lara ; Bhorade, Sangeeta ; Ison, Michael ; Wolfe, Cameron ; Aslam, Saima ; Budem, Marie ; Musetti, Ana

Keywords:

Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, Transplantation, invasive fungal disease, lomentosporiosis, scedosporiosis, solid organ transplantation, RESPIRATORY-TRACT SPECIMENS, CYSTIC-FIBROSIS PATIENT, ANTIFUNGAL PROPHYLAXIS, APIOSPERMUM INFECTION, CLINICAL-SIGNIFICANCE, AIRWAY COLONIZATION, MOLD INFECTIONS, AORTIC-ANEURYSM, SPUTUM SAMPLES, VORICONAZOLE, Ascomycota, Disease Management, Humans, Immunocompromised Host, Internationality, Lung Transplantation, Mycoses, Prospective Studies, Respiratory Tract Infections, Scedosporium, Surveys and Questionnaires, SCEDO-LUNG collaborative group, 1103 Clinical Sciences, Surgery, 3202 Clinical sciences

Abstract:

BACKGROUND: Scedosporium species and Lomentospora prolificans (S/L) are the second most common causes of invasive mold infections following Aspergillus in lung transplant recipients. METHODS: We assessed the current practices on management of S/L colonization/infection of the lower respiratory tract before and after lung transplantation in a large number of lung transplant centers through an international practice survey from October 2016 to March 2017. RESULTS: A total of 51 respondents from 45 lung transplant centers (17 countries, 4 continents) answered the survey (response rate 58%). S/L colonization was estimated to be detected in candidates by 48% of centers. Only 18% of the centers used a specific medium to detect S/L colonization. Scedosporium spp. colonization was a contraindication to transplantation in 10% of centers whereas L prolificans was a contraindication in 31%; 22% of centers declared having had 1-5 recipients infected with S/L in the past 5 years. CONCLUSIONS: This survey gives an overview of the current practices regarding S/L colonization and infection in lung transplant centers worldwide and underscores the need of S/L culture procedure standardization before implementing prospective studies.