Production and Supply of α-Particle-Emitting Radionuclides for Targeted α-Therapy.

Radchenko, Valery; Morgenstern, Alfred; Jalilian, Amir R; Ramogida, Caterina F; Cutler, Cathy; Duchemin, Charlotte; Hoehr, Cornelia; Haddad, Ferrid; Bruchertseifer, Frank; Gausemel, Haavar; Yang, Hua; Osso, Joao Alberto; Washiyama, Kohshin; Czerwinski, Kenneth; Leufgen, Kirsten; Pruszyński, Marek; Valzdorf, Olga; Causey, Patrick; Schaffer, Paul; Perron, Randy; Maxim, Samsonov; Wilbur, D Scott; Stora, Thierry; Li, Yawen

doi:10.2967/jnumed.120.261016

Production and Supply of α-Particle-Emitting Radionuclides for Targeted α-Therapy.

Author:

Radchenko, Valery

Morgenstern, Alfred ; Jalilian, Amir R ; Ramogida, Caterina F ; Cutler, Cathy ; Duchemin, Charlotte ; Hoehr, Cornelia ; Haddad, Ferrid ; Bruchertseifer, Frank ; Gausemel, Haavar ; Yang, Hua ; Osso, Joao Alberto ; Washiyama, Kohshin ; Czerwinski, Kenneth ; Leufgen, Kirsten ; Pruszyński, Marek ; Valzdorf, Olga ; Causey, Patrick ; Schaffer, Paul ; Perron, Randy ; Maxim, Samsonov ; Wilbur, D Scott ; Stora, Thierry ; Li, Yawen

Keywords:

211At, 212Pb/212Bi, 225Ac/213Bi, 227Th/223Ra, production and supply of radionuclides, targeted α-therapy, Alpha Particles, Radioisotopes, Humans, Radiopharmaceuticals, 1103 Clinical Sciences, Nuclear Medicine & Medical Imaging, 3202 Clinical sciences

Abstract:

Encouraging results from targeted α-therapy have received significant attention from academia and industry. However, the limited availability of suitable radionuclides has hampered widespread translation and application. In the present review, we discuss the most promising candidates for clinical application and the state of the art of their production and supply. In this review, along with 2 forthcoming reviews on chelation and clinical application of α-emitting radionuclides, The Journal of Nuclear Medicine will provide a comprehensive assessment of the field.