npj Breast Cancer
Author:
Keywords:
Science & Technology, Life Sciences & Biomedicine, Oncology, INFILTRATING LYMPHOCYTES, FREE SURVIVAL, TRASTUZUMAB, G059821N#56124601, 3202 Clinical sciences, 3211 Oncology and carcinogenesis, 4202 Epidemiology
Abstract:
The vast majority of studies investigating immune checkpoint inhibition (ICI) in patients with breast cancer have focused on triple-negative breast cancer (TNBC). In this study, we compared the tumor immune microenvironment (TIME) between TNBC and hormone receptor-negative HER2-positive breast cancer based on a selection of immune markers at the protein level in an institutional retrospective series. Additionally, we performed a similar comparison using publicly available transcriptomics data. Altogether, the results show a comparable TIME in both groups, with possible implications for the use of ICI in patients with hormone receptor-negative HER2-positive breast tumors.