Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Oncology, Surgery, Conservation surgery, Laryngeal carcinoma, Oncological outcomes, Prognostic factors, Salvage surgery, Total laryngectomy, Transoral laser microsurgery, Squamous cell carcinoma, TRANSORAL LASER MICROSURGERY, SUPRACRICOID PARTIAL LARYNGECTOMY, ELECTIVE NECK DISSECTION, ORGAN-PRESERVATION THERAPY, EARLY GLOTTIC CANCER, RADIATION-FAILURE, FUNCTIONAL OUTCOMES, ROBOTIC SURGERY, RADIOTHERAPY FAILURE, SUPRAGLOTTIC LARYNX, Carcinoma, Squamous Cell, Chemoradiotherapy, Humans, Laryngeal Neoplasms, Laryngectomy, Laser Therapy, Microsurgery, Neoplasm Recurrence, Local, Neoplasm, Residual, Prognosis, Robotic Surgical Procedures, Salvage Therapy, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, 3202 Clinical sciences, 3211 Oncology and carcinogenesis

Abstract:

Nonsurgical primary treatment of early and advanced laryngeal squamous cell carcinoma, employing radiotherapy with or without chemotherapy, is considered a standard of care in many centers throughout the world. When patients have persistent or recurrent disease after non-surgical treatment, salvage surgery is frequently the only remaining potentially curative treatment. Depending on the extent of the residual/recurrent disease, different surgical salvage options are at the surgeon's disposal. In selected cases with limited local disease, salvage transoral laser microsurgery, transoral robotic surgery and open partial laryngectomies can be employed to achieve cure while preserving laryngeal function. For more advanced cases total laryngectomy is necessary. Identifying situations with unacceptable results from surgical salvage may guide future therapies.