Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Virology, HIV-1, nuclear import, integrase, capsid, transportin-SR2, TRN-SR2, TNPO3, CPSF6, IMMUNODEFICIENCY-VIRUS TYPE-1, RNA RECOGNITION MOTIF, NONDIVIDING CELLS, INTEGRASE MUTANTS, TERMINAL DOMAIN, HOST FACTORS, PROTEIN, INFECTION, BINDING, IDENTIFICATION, Active Transport, Cell Nucleus, Capsid, Cyclophilin A, HIV Infections, HIV Integrase, Host-Pathogen Interactions, Humans, Models, Biological, Protein Binding, Virus Replication, beta Karyopherins, mRNA Cleavage and Polyadenylation Factors, S000319N#55542645, 0605 Microbiology, 3107 Microbiology

Abstract:

The HIV replication cycle depends on the interaction of viral proteins with proteins of the host. Unraveling host-pathogen interactions during the infection is of great importance for understanding the pathogenesis and the development of antiviral therapies. To date HIV uncoating and nuclear import are the most debated steps of the HIV-1 replication cycle. Despite numerous studies during past decades, there is still much controversy with respect to the identity and the role of viral and host factors involved in these processes. In this review, we provide a comprehensive overview on the role of transportin-SR2 as a host cell factor during active nuclear transport.