< /SUP>68< //SUP>Ga-DOTATATE PET/CT Distinguishes Neuroendocrine Tumor Mesenteric Lymph Node Metastasis From an Extensive IgG4-Positive Fibrosis Surrounding It

Ahmadi Bidakhvidi, Niloefar; Cuyle, Pieter-Jan; Sagaert, Xavier; Ballaux, Florence; Deroose, Christophe M

doi:10.1097/RLU.0000000000003722

< /SUP>68< //SUP>Ga-DOTATATE PET/CT Distinguishes Neuroendocrine Tumor Mesenteric Lymph Node Metastasis From an Extensive IgG4-Positive Fibrosis Surrounding It

Author:

Ahmadi Bidakhvidi, Niloefar

Cuyle, Pieter-Jan ; Sagaert, Xavier ; Ballaux, Florence ; Deroose, Christophe M

Keywords:

Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, neuroendocrine tumor, small bowel, Ga-68-DOTATATE, IgG4, mesenteric lymph node, fibrosis, Female, Fibrosis, Humans, Immunoglobulin G, Lymphatic Metastasis, Middle Aged, Neuroendocrine Tumors, Organometallic Compounds, Positron Emission Tomography Computed Tomography, 1103 Clinical Sciences, Nuclear Medicine & Medical Imaging, 3202 Clinical sciences

Abstract:

A 56-year-old woman presented with right iliac fossa pain. Abdominal CT showed a mesenteric mass in the right iliac fossa, adjacent to the vena cava inferior and right ureter. Biopsy of the mass revealed a well-differentiated neuroendocrine tumor. 68Ga-DOTATATE PET/CT showed strong somatostatin receptor expression only within in a small, central area of this mesenteric mass, with faint 68Ga-DOTATATE uptake in the majority of this mesenteric mass. Pathology revealed an IgG4-positive storiform fibrosis surrounding a mesenteric adenopathy. 68Ga-DOTATATE PET/CT discriminates between neuroendocrine tumor lymph node metastases and fibrosis, hereby avoiding potential sampling error of tumor biopsies and guiding surgical approach.