Neurology
Publication date:
2021-06-08
Volume:
96
Pages:
E2824 -
E2838
Publisher:
American Academy of Neurology
Author:
Nogueira, Raul G
Qureshi, Muhammad M ; Abdalkader, Mohamad ; Martins, Sheila Ouriques ; Yamagami, Hiroshi ; Qiu, Zhongming ; Mansour, Ossama Yassin ; Sathya, Anvitha ; Czlonkowska, Anna ; Tsivgoulis, Georgios ; Aguiar de Sousa, Diana ; Demeestere, Jelle ; Mikulik, Robert ; Vanacker, Peter ; Siegler, James E ; Korv, Janika ; Biller, Jose ; Liang, Conrad W ; Sangha, Navdeep S ; Zha, Alicia M ; Czap, Alexandra L ; Holmstedt, Christine Anne ; Turan, Tanya N ; Ntaios, George ; Malhotra, Konark ; Tayal, Ashis ; Loochtan, Aaron ; Ranta, Annamarei ; Mistry, Eva A ; Alexandrov, Anne W ; Huang, David Y ; Yaghi, Shadi ; Raz, Eytan ; Sheth, Sunil A ; Mohammaden, Mahmoud H ; Frankel, Michael ; Bila Lamou, Eric Guemekane ; Aref, Hany M ; Elbassiouny, Ahmed ; Hassan, Farouk ; Menecie, Tarek ; Mustafa, Wessam ; Shokri, Hossam M ; Roushdy, Tamer ; Sarfo, Fred S ; Alabi, Tolulope Oyetunde ; Arabambi, Babawale ; Nwazor, Ernest O ; Sunmonu, Taofiki Ajao ; Wahab, Kolawole ; Yaria, Joseph ; Mohammed, Haytham Hussein ; Adebayo, Philip B ; Riahi, Anis D ; Ben Sassi, Samia ; Gwaunza, Lenon ; Ngwende, Gift Wilson ; Sahakyan, David ; Rahman, Aminur ; Ai, Zhibing ; Bai, Fanghui ; Duan, Zhenhui ; Hao, Yonggang ; Huang, Wenguo ; Li, Guangwen ; Li, Wei ; Liu, Ganzhe ; Luo, Jun ; Shang, Xianjin ; Sui, Yi ; Tian, Ling ; Wen, Hongbin ; Wu, Bo ; Yan, Yuying ; Yuan, Zhengzhou ; Zhang, Hao ; Zhang, Jun ; Zhao, Wenlong ; Zi, Wenjie ; Leung, Thomas W ; Chugh, Chandril ; Huded, Vikram ; Menon, Bindu ; Pandian, Jeyaraj Durai ; Sylaja, PN ; Usman, Fritz Sumantri ; Farhoudi, Mehdi ; Hokmabadi, Elyar Sadeghi ; Horev, Anat ; Reznik, Anna ; Hoffmann, Rotem Sivan ; Ohara, Nobuyuki ; Sakai, Nobuyuki ; Watanabe, Daisuke ; Yamamoto, Ryoo ; Doijiri, Ryosuke ; Tokuda, Naoki ; Yamada, Takehiro ; Terasaki, Tadashi ; Yazawa, Yukako ; Uwatoko, Takeshi ; Dembo, Tomohisa ; Shimizu, Hisao ; Sugiura, Yuri ; Miyashita, Fumio ; Fukuda, Hiroki ; Miyake, Kosuke ; Shimbo, Junsuke ; Sugimura, Yusuke ; Yagita, Yoshiki ; Takenobu, Yohei ; Matsumaru, Yuji ; Yamada, Satoshi ; Kono, Ryuhei ; Kanamaru, Takuya ; Yamazaki, Hidekazu ; Sakaguchi, Manabu ; Todo, Kenichi ; Yamamoto, Nobuaki ; Sonoda, Kazutaka ; Yoshida, Tomoko ; Hashimoto, Hiroyuki ; Nakahara, Ichiro ; Kondybayeva, Aida ; Faizullina, Kamila ; Kamenova, Saltanat ; Zhanuzakov, Murat ; Baek, Jang-Hyun ; Hwang, Yangha ; Lee, Jin Soo ; Lee, Si Baek ; Moon, Jusun ; Park, Hyungjong ; Seo, Jung Hwa ; Seo, Kwon-Duk ; Sohn, Sung Il ; Young, Chang Jun ; Ahdab, Rechdi ; Zaidi, Wan Asyraf Wan ; Aziz, Zariah Abdul ; bin Basri, Hamidon ; Chung, Law Wan ; Ibrahim, Aznita Binti ; Ibrahim, Khairul Azmi ; Looi, Irene ; Tan, Wee Yong ; Yahya, Nafisah Wan ; Groppa, Stanislav ; Leahu, Pavel ; Al Hashmi, Amal M ; Imam, Yahia Zakaria ; Akhtar, Naveed ; Pineda-Franks, Maria Carissa ; Co, Christian Oliver ; Kandyba, Dmitriy ; Alhazzani, Adel ; Al-Jehani, Hosam ; Tham, Carol Huilian ; Mamauag, Marlie Jane ; Venketasubramanian, Narayanaswamy ; Chen, Chih-Hao ; Tang, Sung-Chun ; Churojana, Anchalee ; Akil, Esref ; Aykac, Ozlem ; Ozdemir, Atilla Ozcan ; Giray, Semih ; Hussain, Syed Irteza ; John, Seby ; Huynh, Le Vu ; Anh, Duc Tran ; Huy, Hoang Nguyen ; Thong, Nhu Pham ; Thang, Huy Nguyen ; Trung, Quoc Nguyen ; Gattringer, Thomas ; Enzinger, Christian ; Killer-Oberpfalzer, Monika ; Bellante, Flavio ; De Blauwe, Sofie ; Vanhooren, Geert ; De Raedt, Sylvie ; Dusart, Anne ; Lemmens, Robin ; Ligot, Noemie ; Rutgers, Matthieu Pierre ; Yperzeele, Laetitia ; Alexiev, Filip ; Sakelarova, Teodora ; Bedekovic, Marina Roje ; Budincevic, Hrvoje ; Cindric, Igor ; Hucik, Zlatko ; Ozretic, David ; Saric, Majda Seferovic ; Pfeifer, Frantisek ; Karpowic, Igor ; Cernik, David ; Sramek, Martin ; Skoda, Miroslav ; Hlavacova, Helena ; Klecka, Lukas ; Koutny, Martin ; Vaclavik, Daniel ; Skoda, Ondrej ; Fiksa, Jan ; Hanelova, Katerina ; Nevsimalova, Miroslava ; Rezek, Robert ; Prochazka, Petr ; Krejstova, Gabriela ; Neumann, Jiri ; Vachova, Marta ; Brzezanski, Henryk ; Hlinovsky, David ; Tenora, Dusan ; Jura, Rene ; Jurak, Lubomir ; Novak, Jan ; Novak, Ales ; Topinka, Zdenek ; Fibrich, Petr ; Sobolova, Helena ; Volny, Ondrej ; Christensen, Hanne Krarup ; Drenck, Nicolas ; Iversen, Helle Klingenberg ; Simonsen, Claus Z ; Truelsen, Thomas Clement ; Wienecke, Troels ; Vibo, Riina ; Gross-Paju, Katrin ; Toomsoo, Toomas ; Antsov, Katrin ; Caparros, Francois ; Cordonnier, Charlotte ; Dan, Maria ; Faucheux, Jean-Marc ; Mechtouff, Laura ; Eker, Omer ; Lesaine, Emilie ; Ondze, Basile ; Peres, Roxane ; Pico, Fernando ; Piotin, Michel ; Pop, Raoul ; Rouanet, Francois ; Gubeladze, Tatuli ; Khinikadze, Mirza ; Lobjanidze, Nino ; Tsiskaridze, Alexander ; Nagel, Simon ; Ringleb, Peter Arthur ; Rosenkranz, Michael ; Schmidt, Holger ; Sedghi, Annahita ; Siepmann, Timo ; Szabo, Kristina ; Thomalla, Goetz ; Palaiodimou, Lina ; Sagris, Dimitrios ; Kargiotis, Odysseas ; Klivenyi, Peter ; Szapary, Laszlo ; Tarkanyi, Gabor ; Adami, Alessandro ; Bandini, Fabio ; Calabresi, Paolo ; Frisullo, Giovanni ; Renieri, Leonardo ; Sangalli, Davide ; Pirson, Anne ; Uyttenboogaart, Maarten ; van den Wijngaard, Ido ; Kristoffersen, Espen Saxhaug ; Brola, Waldemar ; Fudala, Malgorzata ; Horoch-Lyszczarek, Ewa ; Karlinski, Michal ; Kazmierski, Radoslaw ; Kram, Pawel ; Rogoziewicz, Marcin ; Kaczorowski, Rafal ; Luchowski, Piotr ; Sienkiewicz-Jarosz, Halina ; Sobolewski, Piotr ; Fryze, Waldemar ; Wisniewska, Anna ; Wiszniewska, Malgorzata ; Ferreira, Patricia ; Ferreira, Paulo ; Fonseca, Luisa ; Marto, Joao Pedro ; Pinho e Melo, Teresa ; Nunes, Ana Paiva ; Rodrigues, Miguel ; Cruz, Vitor Tedim ; Falup-Pecurariu, Cristian ; Krastev, Georgi ; Mako, Miroslav ; Alonso de Lecinana, Maria ; Arenillas, Juan F ; Ayo-Martin, Oscar ; Cruz Culebras, Antonio ; Diez Tejedor, Exuperio ; Montaner, Joan ; Perez-Sanchez, Soledad ; Tola Arribas, Miguel Angel ; Rodriguez Vasquez, Alejandro ; Mayza, Michael ; Bernava, Gianmarco ; Brehm, Alex ; Machi, Paolo ; Fischer, Urs ; Gralla, Jan ; Michel, Patrik L ; Psychogios, Marios-Nikos ; Strambo, Davide ; Banerjee, Soma ; Krishnan, Kailash ; Kwan, Joseph ; Butt, Asif ; Catanese, Luciana ; Demchuk, Andrew M ; Field, Thalia ; Haynes, Jennifer ; Hill, Michael D ; Khosravani, Houman ; Mackey, Ariane ; Pikula, Aleksandra ; Saposnik, Gustavo ; Scott, Courtney Anne ; Shoamanesh, Ashkan ; Shuaib, Ashfaq ; Yip, Samuel ; Barboza, Miguel A ; Domingo Barrientos, Jose ; Portillo Rivera, Ligia Ibeth ; Gongora-Rivera, Fernando ; Novarro-Escudero, Nelson ; Blanco, Anmylene ; Abraham, Michael ; Alsbrook, Diana ; Altschul, Dorothea ; Alvarado-Ortiz, Anthony J ; Bach, Ivo ; Badruddin, Aamir ; Barazangi, Nobl ; Brereton, Charmaine ; Castonguay, Alicia ; Chaturvedi, Seemant ; Chaudry, Saqib A ; Choe, Hana ; Choi, Jae H ; Dharmadhikari, Sushrut ; Desai, Kinjal ; Devlin, Thomas G ; Doss, Vinodh T ; Edgell, Randall ; Etherton, Mark ; Farooqui, Mudassir ; Frei, Don ; Gandhi, Dheeraj ; Grigoryan, Mikayel ; Gupta, Rishi ; Hassan, Ameer E ; Helenius, Johanna ; Kaliaev, Artem ; Kaushal, Ritesh ; Khandelwal, Priyank ; Khawaja, Ayaz M ; Khoury, Naim N ; Kim, Benny S ; Kleindorfer, Dawn O ; Koyfman, Feliks ; Lee, Vivien H ; Leung, Lester Y ; Linares, Guillermo ; Linfante, Italo ; Lutsep, Helmi L ; Macdougall, Lisa ; Male, Shailesh ; Malik, Amer M ; Masoud, Hesham ; McDermott, Molly ; Mehta, Brijesh P ; Min, Jiangyong ; Mittal, Manoj ; Morris, Jane G ; Multani, Sumeet S ; Nahab, Fadi ; Nalleballe, Krishna ; Nguyen, Claude B ; Novakovic-White, Roberta ; Ortega-Gutierrez, Santiago ; Rahangdale, Rahul H ; Ramakrishnan, Pankajavalli ; Romero, Jose Rafael ; Rost, Natalia ; Rothstein, Aaron ; Ruland, Sean ; Shah, Ruchir ; Sharma, Malveeka ; Silver, Brian ; Simmons, Marc ; Singh, Abhishek ; Starosciak, Amy K ; Strasser, Sheryl L ; Szeder, Viktor ; Teleb, Mohamed ; Tsai, Jenny P ; Voetsch, Barbara ; Balaguera, Oscar ; Pujol Lereis, Virginia A ; Luraschi, Adriana ; Almeida, Marcele Schettini ; Cardoso, Fabricio Buchdid ; Conforto, Adriana ; Silva, Leonardo De Deus ; Giacomini, Luidia Varrone ; Lima, Fabricio Oliveira ; Longo, Alexandre L ; Magalhaes, Pedro SC ; Martins, Rodrigo Targa ; Mont'alverne, Francisco ; Mora Cuervo, Daissy Liliana ; Rebello, Leticia Costa ; Valler, Lenise ; Zetola, Viviane Flumignan ; Lavados, Pablo M ; Navia, Victor ; Olavarria, Veronica V ; Almeida Toro, Juan Manuel ; Ricardo Amaya, Pablo Felipe ; Bayona, Hernan ; Corredor, Angel ; Rivera Ordonez, Carlos Eduardo ; Mantilla Barbosa, Diana Katherine ; Lara, Osvaldo ; Patino, Mauricio R ; Diaz Escobar, Luis Fernando ; Melgarejo Farina, Donoband Edson Dejesus ; Cardozo Villamayor, Analia ; Zelaya Zarza, Adolfo Javier ; Barrientos Iman, Danny Moises ; Rodriguez Kadota, Liliana ; Campbell, Bruce ; Hankey, Graeme J ; Hair, Casey ; Kleinig, Timothy ; Ma, Alice ; Martins, Rodrigo Tomazini ; Sahathevan, Ramesh ; Thijs, Vincent ; Salazar, Daniel ; Wu, Teddy Yuan-Hao ; Haussen, Diogo C ; Liebeskind, David ; Yavagal, Dileep R ; Jovin, Tudor G ; Zaidat, Osama O ; Nguyen, Thanh N
Keywords:
Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, COVID-19, Cross-Sectional Studies, Hospitalization, Humans, Pandemics, Retrospective Studies, SARS-CoV-2, Stroke, Thrombolytic Therapy, SVIN COVID-19 Global Stroke Registry, 1103 Clinical Sciences, 1109 Neurosciences, 1702 Cognitive Sciences, Neurology & Neurosurgery, 3202 Clinical sciences, 3209 Neurosciences
Abstract:
OBJECTIVE: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. METHODS: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. RESULTS: There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95% confidence interval [CI] -11.7 to -11.3, p < 0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95% CI -13.8 to -12.7, p < 0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95% CI -13.7 to -10.3, p = 0.001). Recovery of stroke hospitalization volume (9.5%, 95% CI 9.2-9.8, p < 0.0001) was noted over the 2 later (May, June) vs the 2 earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was noted in 3.3% (1,722/52,026) of all stroke admissions. CONCLUSIONS: The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID-19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.