Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes

Wawina-Bokalanga, Tony; Vanmechelen, Bert; Lhermitte, Valentine; Marti-Carreras, Joan; Vergote, Valentijn; Koundouno, Fara Raymond; Akoi-Bore, Joseph; Thom, Ruth; Tipton, Tom; Steeds, Kimberley; Moussa, Keita Balla; Amento, Ablam; Laenen, Lies; Duraffour, Sophie; Gabriel, Martin; Ruibal, Paula; Hall, Yper; Kader-Kond, Mandy; Gunther, Stephan; Baele, Guy; Munoz-Fontela, Cesar; Van Weyenbergh, Johan; Carroll, Miles W; Maes, Piet

doi:10.3201/eid2701.202177

Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes

Author:

Wawina-Bokalanga, Tony

Vanmechelen, Bert ; Lhermitte, Valentine ; Marti-Carreras, Joan ; Vergote, Valentijn ; Koundouno, Fara Raymond ; Akoi-Bore, Joseph ; Thom, Ruth ; Tipton, Tom ; Steeds, Kimberley ; Moussa, Keita Balla ; Amento, Ablam ; Laenen, Lies ; Duraffour, Sophie ; Gabriel, Martin ; Ruibal, Paula ; Hall, Yper ; Kader-Kond, Mandy ; Gunther, Stephan ; Baele, Guy ; Munoz-Fontela, Cesar ; Van Weyenbergh, Johan ; Carroll, Miles W ; Maes, Piet

Keywords:

Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, HEMORRHAGIC-FEVER, STOPPING RULES, NK CELLS, KIR, SELECTION, HLA, POLYMORPHISMS, PATHOGENESIS, Ebola virus disease, Ebola virus infection, Guinea, Zaire ebolavirus, human leukocyte antigens, human leukocyte antigens class I, killer cell immunoglobulin-like receptor genes, killer cell immunoglobulin-like receptors, natural killer cells, viral zoonoses, viruses, zoonoses, Alleles, Bayes Theorem, Genotype, HLA Antigens, Hemorrhagic Fever, Ebola, Humans, Receptors, KIR, STG/17/003#54272001, C14/18/094#54689608, 1103 Clinical Sciences, 1108 Medical Microbiology, 1117 Public Health and Health Services, Microbiology, 3202 Clinical sciences, 4202 Epidemiology, 4203 Health services and systems

Abstract:

We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). We genotyped KIRs and HLA class I alleles using DNA from uninfected controls, EVD survivors, and persons who died of EVD. The activating 2DS4-003 and inhibitory 2DL5 genes were significantly more common among persons who died of EVD; 2DL2 was more common among survivors. We used logistic regression analysis and Bayesian modeling to identify 2DL2, 2DL5, 2DS4-003, HLA-B-Bw4-Thr, and HLA-B-Bw4-Ile as probably having a significant relationship with disease outcome. Our findings highlight the importance of innate immune response against Ebola virus and show the association between KIRs and the clinical outcome of EVD.