Free 25-hydroxyvitamin D: impact of vitamin D binding protein assays on racial-genotypic associations

Nielson, Carrie M; Jones, Kerry S; Chun, Rene F; Jacobs, Jon M; Wang, Ying; Hewison, Martin; Adams, John S; Swanson, Christine M; Lee, Christine G; Vanderschueren, Dirk; Pauwels, Steven; Prentice, Ann; Smith, Richard D; Shi, Tujin; Gao, Yuqian; Schepmoes, Athena A; Zmuda, Joseph M; Lapidus, Jodi; Cauley, Jane A; Bouillon, Roger; Schoenmakers, Inez; Orwoll, Eric S

doi:10.1210/jc.2016-1104

Free 25-hydroxyvitamin D: impact of vitamin D binding protein assays on racial-genotypic associations

Author:

Nielson, Carrie M

Jones, Kerry S ; Chun, Rene F ; Jacobs, Jon M ; Wang, Ying ; Hewison, Martin ; Adams, John S ; Swanson, Christine M ; Lee, Christine G ; Vanderschueren, Dirk ; Pauwels, Steven ; Prentice, Ann ; Smith, Richard D ; Shi, Tujin ; Gao, Yuqian ; Schepmoes, Athena A ; Zmuda, Joseph M ; Lapidus, Jodi ; Cauley, Jane A ; Bouillon, Roger ; Schoenmakers, Inez ; Orwoll, Eric S

Keywords:

Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, BONE-MINERAL DENSITY, GENETIC-VARIANTS, D DEFICIENCY, SERUM, AFFINITY, METABOLITES, CALCIUM, Adult, Aged, Black People, Cross-Sectional Studies, Humans, Male, Vitamin D, Vitamin D-Binding Protein, White People, Osteoporotic Fractures in Men (MrOS) Research Group, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 3202 Clinical sciences

Abstract:

Total 25-hydroxyvitamin D (25OHD) is a marker of vitamin D status and is lower in African Americans than in whites. Whether this difference holds for free 25OHOD (f25OHD) is unclear, considering reported genetic-racial differences in vitamin D binding protein (DBP) used to calculate f25OHD.