Nature
Publication date:
2020-06-04
Volume:
582
Pages:
73 -
Publisher:
Nature Research
Author:
Taddei, Cristina
Zhou, Bin ; Bixby, Honor ; Carrillo-Larco, Rodrigo M ; Danaei, Goodarz ; Jackson, Rod T ; Farzadfar, Farshad ; Sophiea, Marisa K ; Di Cesare, Mariachiara ; Iurilli, Maria Laura Caminia ; Martinez, Andrea Rodriguez ; Asghari, Golaleh ; Dhana, Klodian ; Gulayin, Pablo ; Kakarmath, Sujay ; Santero, Marilina ; Voortman, Trudy ; Riley, Leanne M ; Cowan, Melanie J ; Savin, Stefan ; Bennett, James E ; Stevens, Gretchen A ; Paciorek, Christopher J ; Aekplakorn, Wichai ; Cifkova, Renata ; Giampaoli, Simona ; Kengne, Andre Pascal ; Khang, Young-Ho ; Kuulasmaa, Kari ; Laxmaiah, Avula ; Margozzini, Paula ; Mathur, Prashant ; Nordestgaard, Borge G ; Zhao, Dong ; Aadahl, Mette ; Abarca-Gomez, Leandra ; Rahim, Hanan Abdul ; Abu-Rmeileh, Niveen M ; Acosta-Cazares, Benjamin ; Adams, Robert J ; Agdeppa, Imelda A ; Aghazadeh-Attari, Javad ; Aguilar-Salinas, Carlos A ; Agyemang, Charles ; Ahluwalia, Tarunveer S ; Ahmad, Noor Ani ; Ahmadi, Ali ; Ahmadi, Naser ; Ahmed, Soheir H ; Ahrens, Wolfgang ; Ajlouni, Kamel ; Alarouj, Monira ; AlBuhairan, Fadia ; AlDhukair, Shahla ; Ali, Mohamed M ; Alkandari, Abdullah ; Alkerwi, Ala'a ; Aly, Eman ; Amarapurkar, Deepak N ; Amouyel, Philippe ; Andersen, Lars Bo ; Anderssen, Sigmund A ; Anjana, Ranjit Mohan ; Ansari-Moghaddam, Alireza ; Aounallah-Skhiri, Hajer ; Araujo, Joana ; Ariansen, Inger ; Aris, Tahir ; Arku, Raphael E ; Arlappa, Nimmathota ; Aryal, Krishna K ; Aspelund, Thor ; Assuncao, Maria Cecilia F ; Auvinen, Juha ; Avdicova, Maria ; Azevedo, Ana ; Azizi, Fereidoun ; Azmin, Mehrdad ; Balakrishna, Nagalla ; Bamoshmoosh, Mohamed ; Banach, Maciej ; Bandosz, Piotr ; Banegas, Jose R ; Barbagallo, Carlo M ; Barcelo, Alberto ; Barkat, Amina ; Bata, Iqbal ; Batieha, Anwar M ; Batyrbek, Assembekov ; Baur, Louise A ; Beaglehole, Robert ; Belavendra, Antonisamy ; Ben Romdhane, Habiba ; Benet, Mikhail ; Benn, Marianne ; Berkinbayev, Salim ; Bernabe-Ortiz, Antonio ; Bernotiene, Gailute ; Bettiol, Heloisa ; Bhargava, Santosh K ; Bi, Yufang ; Bienek, Asako ; Bikbov, Mukharram ; Bista, Bihungum ; Bjerregaard, Peter ; Bjertness, Espen ; Bjertness, Marius B ; Bjorkelund, Cecilia ; Bloch, Katia ; Blokstra, Anneke ; Bo, Simona ; Boehm, Bernhard O ; Boggia, Jose G ; Boissonnet, Carlos P ; Bonaccio, Marialaura ; Bongard, Vanina ; Borchini, Rossana ; Borghs, Herman ; Bovet, Pascal ; Brajkovich, Imperia ; Breckenkamp, Juergen ; Brenner, Hermann ; Brewster, Lizzy M ; Bruno, Graziella ; Bugge, Anna ; Busch, Markus A ; de Leon, Antonio Cabrera ; Cacciottolo, Joseph ; Can, Gunay ; Candido, Ana Paula C ; Capanzana, Mario ; Capuano, Eduardo ; Capuano, Vincenzo ; Cardoso, Viviane C ; Carvalho, Joana ; Casanueva, Felipe F ; Censi, Laura ; Chadjigeorgiou, Charalambos A ; Chamukuttan, Snehalatha ; Chaturvedi, Nish ; Chen, Chien-Jen ; Chen, Fangfang ; Chen, Shuohua ; Cheng, Ching-Yu ; Cheraghian, Bahman ; Chetrit, Angela ; Chiou, Shu-Ti ; Chirlaque, Maria-Dolores ; Cho, Belong ; Cho, Yumi ; Chudek, Jerzy ; Claessens, Frank ; Clarke, Janine ; Clays, Els ; Concin, Hans ; Confortin, Susana C ; Cooper, Cyrus ; Costanzo, Simona ; Cottel, Dominique ; Cowell, Chris ; Crujeiras, Ana B ; Csilla, Semanova ; Cui, Liufu ; Cureau, Felipe ; D'Arrigo, Graziella ; d'Orsi, Eleonora ; Dallongeville, Jean ; Damasceno, Albertino ; Dankner, Rachel ; Dantoft, Thomas M ; Dauchet, Luc ; Davletov, Kairat ; De Backer, Guy ; De Bacquer, Dirk ; de Gaetano, Giovanni ; De Henauw, Stefaan ; de Oliveira, Paula Duarte ; De Ridder, David ; De Smedt, Delphine ; Deepa, Mohan ; Deev, Alexander D ; Dehghan, Abbas ; Delisle, Helene ; Dennison, Elaine ; Deschamps, Valerie ; Dhimal, Meghnath ; Di Castelnuovo, Augusto F ; Dika, Zivka ; Djalalinia, Shirin ; Dobson, Annette J ; Donfrancesco, Chiara ; Donoso, Silvana P ; Doring, Angela ; Dorobantu, Maria ; Dragano, Nico ; Drygas, Wojciech ; Du, Yong ; Duante, Charmaine A ; Duda, Rosemary B ; Dzerve, Vilnis ; Dziankowska-Zaborszczyk, Elzbieta ; Eddie, Ricky ; Eftekhar, Ebrahim ; Eggertsen, Robert ; Eghtesad, Sareh ; Eiben, Gabriele ; Ekelund, Ulf ; El Ati, Jalila ; Eldemire-Shearer, Denise ; Eliasen, Marie ; Elosua, Roberto ; Erasmus, Rajiv T ; Erbel, Raimund ; Erem, Cihangir ; Eriksen, Louise ; Eriksson, Johan G ; Escobedo-de la Pena, Jorge ; Eslami, Saeid ; Esmaeili, Ali ; Evans, Alun ; Faeh, David ; Fall, Caroline H ; Faramarzi, Elnaz ; Farjam, Mojtaba ; Fattahi, Mohammad Reza ; Felix-Redondo, Francisco J ; Ferguson, Trevor S ; Fernandez-Berges, Daniel ; Ferrante, Daniel ; Ferrari, Marika ; Ferreccio, Catterina ; Ferrieres, Jean ; Foger, Bernhard ; Foo, Leng Huat ; Forslund, Ann-Sofie ; Forsner, Maria ; Fouad, Heba M ; Francis, Damian K ; Franco, Maria do Carmo ; Franco, Oscar H ; Frontera, Guillermo ; Fujita, Yuki ; Fumihiko, Matsuda ; Furusawa, Takuro ; Gaciong, Zbigniew ; Galvano, Fabio ; Gao, Jingli ; Garcia-de-la-Hera, Manoli ; Garnett, Sarah P ; Gaspoz, Jean-Michel ; Gasull, Magda ; Gazzinelli, Andrea ; Geleijnse, Johanna M ; Ghanbari, Ali ; Ghasemi, Erfan ; Gheorghe-Fronea, Oana-Florentina ; Ghimire, Anup ; Gianfagna, Francesco ; Gill, Tiffany K ; Giovannelli, Jonathan ; Gironella, Glen ; Giwercman, Aleksander ; Goltzman, David ; Goncalves, Helen ; Gonzalez-Chica, David A ; Gonzalez-Gross, Marcela ; Gonzalez-Rivas, Juan P ; Gonzalez-Villalpando, Clicerio ; Gonzalez-Villalpando, Maria-Elena ; Gonzalez, Angel R ; Gottrand, Frederic ; Graff-Iversen, Sidsel ; Gregor, Ronald D ; Grodzicki, Tomasz ; Grontved, Anders ; Grosso, Giuseppe ; Gruden, Gabriella ; Gu, Dongfeng ; Guallar-Castillon, Pilar ; Guan, Ong Peng ; Gudmundsson, Elias F ; Gudnason, Vilmundur ; Guerrero, Ramiro ; Guessous, Idris ; Gunnlaugsdottir, Johanna ; Gupta, Rajeev ; Gutierrez, Laura ; Gutzwiller, Felix ; Ha, Seongjun ; Hadaegh, Farzad ; Haghshenas, Rosa ; Hakimi, Hamid ; Hambleton, Ian R ; Hamzeh, Behrooz ; Hantunen, Sari ; Kumar, Rachakulla Hari ; Hashemi-Shahri, Seyed Mohammad ; Hata, Jun ; Haugsgjerd, Teresa ; Hayes, Alison J ; He, Jiang ; He, Yuna ; Hendriks, Marleen Elisabeth ; Henriques, Ana ; Herrala, Sauli ; Heshmat, Ramin ; Hill, Allan G ; Ho, Sai Yin ; Ho, Suzanne C ; Hobbs, Michael ; Hofman, Albert ; Homayounfar, Reza ; Hopman, Wilma M ; Horimoto, Andrea RVR ; Hormiga, Claudia M ; Horta, Bernardo L ; Houti, Leila ; Howitt, Christina ; Htay, Thein Thein ; Htet, Aung Soe ; Htike, Maung Maung Than ; Huerta, Jose Maria ; Huhtaniemi, Ilpo Tapani ; Huisman, Martijn ; Hunsberger, Monica L ; Husseini, Abdullatif S ; Huybrechts, Inge ; Hwalla, Nahla ; Iacoviello, Licia ; Iannone, Anna G ; Ibrahim, Mohsen M ; Wong, Norazizah Ibrahim ; Iglesia, Iris ; Ikeda, Nayu ; Ikram, M Arfan ; Iotova, Violeta ; Irazola, Vilma E ; Ishida, Takafumi ; Islam, Muhammad ; Ismail, Aziz Al-Safi ; Iwasaki, Masanori ; Jacobs, Jeremy M ; Jaddou, Hashem Y ; Jafar, Tazeen ; James, Kenneth ; Jamrozik, Konrad ; Janszky, Imre ; Janus, Edward ; Jarvelin, Marjo-Riitta ; Jasienska, Grazyna ; Jelakovic, Ana ; Jelakovic, Bojan ; Jennings, Garry ; Jensen, Gorm B ; Jeong, Seung-lyeal ; Jha, Anjani Kumar ; Jiang, Chao Qiang ; Jimenez, Ramon O ; Jockel, Karl-Heinz ; Joffres, Michel ; Jokelainen, Jari J ; Jonas, Jost B ; Jorgensen, Torben ; Joshi, Pradeep ; Joukar, Farahnaz ; Jozwiak, Jacek ; Juolevi, Anne ; Kafatos, Anthony ; Kajantie, Eero O ; Kalter-Leibovici, Ofra ; Kamaruddin, Nor Azmi ; Kamstrup, Pia R ; Karki, Khem B ; Katz, Joanne ; Kauhanen, Jussi ; Kaur, Prabhdeep ; Kavousi, Maryam ; Kazakbaeva, Gyulli ; Keil, Ulrich ; Keinanen-Kiukaanniemi, Sirkka ; Kelishadi, Roya ; Keramati, Maryam ; Kerimkulova, Alina ; Kersting, Mathilde ; Khader, Yousef Saleh ; Khalili, Davood ; Khateeb, Mohammad ; Kheradmand, Motahareh ; Khosravi, Alireza ; Kiechl-Kohlendorfer, Ursula ; Kiechl, Stefan ; Killewo, Japhet ; Kim, Hyeon Chang ; Kim, Jeongseon ; Kim, Yeon-Yong ; Klumbiene, Jurate ; Knoflach, Michael ; Ko, Stephanie ; Kohler, Hans-Peter ; Kohler, Iliana ; Kolle, Elin ; Kolsteren, Patrick ; Konig, Jurgen ; Korpelainen, Raija ; PaulKorrovits, ; Kos, Jelena ; Koskinen, Seppo ; Kouda, Katsuyasu ; Kowlessur, Sudhir ; Kratzer, Wolfgang ; Kriemler, Susi ; Kristensen, Peter Lund ; Krokstad, Steiner ; Kromhout, Daan ; Kujala, Urho M ; Kurjata, Pawel ; Kyobutungi, Catherine ; Laamiri, Fatima Zahra ; Laatikainen, Tiina ; Lachat, Carl ; Laid, Youcef ; Lam, Tai Hing ; Lambrinou, Christina-Paulina ; Lanska, Vera ; Lappas, Georg ; Larijani, Bagher ; Latt, Tint Swe ; Laugsand, Lars E ; Lazo-Porras, Maria ; Lee, Jeannette ; Lee, Jeonghee ; Lehmann, Nils ; Lehtimaki, Terho ; Levitt, Naomi S ; Li, Yanping ; Lilly, Christa L ; Lim, Wei-Yen ; Lima-Costa, M Fernanda ; Lin, Hsien-Ho ; Lin, Xu ; Lin, Yi-Ting ; Lind, Lars ; Linneberg, Allan ; Lissner, Lauren ; Liu, Jing ; Loit, Helle-Mai ; Lopez-Garcia, Esther ; Lopez, Tania ; Lotufo, Paulo A ; Lozano, Jose Eugenio ; Luksiene, Dalia ; Lundqvist, Annamari ; Lundqvist, Robert ; Lunet, Nuno ; Ma, Guansheng ; Machado-Coelho, George LL ; Machado-Rodrigues, Aristides M ; Machi, Suka ; Madar, Ahmed A ; Maggi, Stefania ; Magliano, Dianna J ; Magriplis, Emmanuella ; Mahasampath, Gowri ; Maire, Bernard ; Makdisse, Marcia ; Malekzadeh, Fatemeh ; Reza, Malekzadeh ; Rao, Kodavanti Mallikharjuna ; Manios, Yannis ; Mann, Jim ; Mansour-Ghanaei, Fariborz ; Manzato, Enzo ; Marques-Vidal, Pedro ; Martorell, Reynaldo ; Mascarenhas, Luis P ; Mathiesen, Ellisiv B ; Matsha, Tandi E ; Mavrogianni, Christina ; McFarlane, Shelly R ; McGarvey, Stephen T ; McLachlan, Stela ; McLean, Rachael M ; McLean, Scott B ; McNulty, Breige A ; Mediene-Benchekor, Sounnia ; Mehdipour, Parinaz ; Mehlig, Kirsten ; Mehrparvar, AmirHoushang ; Meirhaeghe, Aline ; Meisinger, Christa ; Menezes, Ana Maria B ; Menon, Geetha R ; Merat, Shahin ; Mereke, Alibek ; Meshram, Indrapal I ; Metcalf, Patricia ; Meyer, Haakon E ; Mi, Jie ; Michels, Nathalie ; Miller, Jody C ; Minderico, Claudia S ; Mini, GK ; Miquel, Juan Francisco ; Miranda, J Jaime ; Mirjalili, Mohammad Reza ; Mirrakhimov, Erkin ; Modesti, Pietro A ; Moghaddam, Sahar Saeedi ; Mohajer, Bahram ; Mohamed, MostafaK ; Mohammad, Kazem ; Mohammadi, Zahra ; Mohammadifard, Noushin ; Mohammadpourhodki, Reza ; Mohan, Viswanathan ; Mohanna, Salim ; MohdYusoff, Muhammad Fadhli ; Mohebbi, Iraj ; Mohebi, Farnam ; Moitry, Marie ; Mollehave, Line T ; Moller, Niels C ; Molnar, Denes ; Momenan, Amirabbas ; Mondo, Charles K ; Monterrubio-Flores, Eric ; Moosazadeh, Mahmood ; Morejon, Alain ; Moreno, Luis A ; Morgan, Karen ; Morin, Suzanne N ; Moschonis, George ; Mossakowska, Malgorzata ; Mostafa, Aya ; Mota, Jorge ; Motlagh, Mohammad Esmaeel ; Motta, Jorge ; Msyamboza, Kelias P ; Muiesan, Maria L ; Mueller-Nurasyid, Martina ; Mursu, Jaakko ; Mustafa, Norlaila ; Nabipour, Iraj ; Naderimagham, Shohreh ; Nagel, Gabriele ; Naidu, Balkish M ; Najafi, Farid ; Nakamura, Harunobu ; Nang, Ei Ei K ; Nangia, Vinay B ; Nauck, Matthias ; Neal, William A ; Nejatizadeh, Azim ; Nenko, Ilona ; Nervi, Flavio ; Nguyen, Nguyen D ; Quang, Ngoc Nguyen ; Nieto-Martinez, Ramfis E ; Nihal, Thomas ; Niiranen, Teemu J ; Ning, Guang ; Ninomiya, Toshiharu ; Noale, Marianna ; Noboa, Oscar A ; Noto, Davide ; Al Nsour, Mohannad ; Nuhoglu, Irfan ; O'Neill, Terence W ; O'Reilly, Dermot ; Ochoa-Aviles, Angelica M ; Oh, Kyungwon ; Ohtsuka, Ryutaro ; Olafsson, Orn ; Olie, Valerie ; Oliveira, Isabel O ; Omar, Mohd Azahadi ; Onat, Altan ; Ong, SokKing ; Ordunez, Pedro ; Ornelas, Rui ; Ortiz, Pedro J ; Osmond, Clive ; Ostojic, Sergej M ; Ostovar, Afshin ; Otero, Johanna A ; Owusu-Dabo, Ellis ; Paccaud, Fred Michel ; Pahomova, Elena ; Pajak, Andrzej ; Palmieri, Luigi ; Pan, Wen-Harn ; Panda-Jonas, Songhomitra ; Panza, Francesco ; Parnell, Winsome R ; Patel, Nikhil D ; Peer, Nasheeta ; Peixoto, Sergio Viana ; Peltonen, Markku ; Pereira, Alexandre C ; Peters, Annette ; Petersmann, Astrid ; Petkeviciene, Janina ; Peykari, Niloofar ; Son, Thai Pham ; Pichardo, Rafael N ; Pigeot, Iris ; Pilav, Aida ; Pilotto, Lorenza ; Piwonska, Aleksandra ; Pizarro, Andreia N ; Plans-Rubio, Pedro ; Plata, Silvia ; Pohlabeln, Hermann ; Porta, Miquel ; Portegies, Marileen LP ; Poudyal, Anil ; Pourfarzi, Farhad ; Poustchi, Hossein ; Pradeepa, Rajendra ; Price, Jacqueline F ; Providencia, Rui ; Puder, Jardena J ; Puhakka, Soile E ; Punab, Margus ; Qorbani, Mostafa ; Tran, Quoc Bao ; Radisauskas, Ricardas ; Rahimikazerooni, Salar ; Raitakari, Olli ; Rao, Sudha Ramachandra ; Ramachandran, Ambady ; Ramos, Elisabete ; Ramos, Rafel ; Rampal, Lekhraj ; Rampal, Sanjay ; Redon, Josep ; Reganit, Paul Ferdinand M ; Revilla, Luis ; Rezaianzadeh, Abbas ; Ribeiro, Robespierre ; Richter, Adrian ; Rigo, Fernando ; de Wit, Tobias F Rinke ; Rodriguez-Artalejo, Fernando ; Rodriguez-Perez, Maria del Cristo ; Rodriguez-Villamizar, Laura A ; Roggenbuck, Ulla ; Rojas-Martinez, Rosalba ; Romaguera, Dora ; Romeo, Elisabetta L ; Rosengren, Annika ; Roy, Joel GR ; Rubinstein, Adolfo ; Ruidavets, Jean-Bernard ; Ruiz-Betancourt, Blanca Sandra ; Russo, Paola ; Rust, Petra ; Rutkowski, Marcin ; Sabanayagam, Charumathi ; Sachdev, Harshpal S ; Sadjadi, Alireza ; Safarpour, Ali Reza ; Safiri, Saeid ; Saidi, Olfa ; Saki, Nader ; Salanave, Benoit ; Salmeron, Diego ; Salomaa, Veikko ; Salonen, Jukka T ; Salvetti, Massimo ; Sanchez-Abanto, Jose ; Sans, Susana ; Santaliestra-Pasias, Alba M ; Santos, Diana A ; Santos, MariaPaula ; Santos, Rute ; Saramies, Jouko L ; Sardinha, Luis B ; Sarrafzadegan, Nizal ; Saum, Kai-Uwe ; Savva, Savvas C ; Sawada, Norie ; Sbaraini, Mariana ; Scazufca, Marcia ; Schaan, Beatriz D ; Schargrodsky, Herman ; Scheidt-Nave, Christa ; Schienkiewitz, Anja ; Schipf, Sabine ; Schmidt, Carsten O ; Schottker, Ben ; Schramm, Sara ; Sebert, Sylvain ; Sein, Aye Aye ; Sen, Abhijit ; Sepanlou, Sadaf G ; Servais, Jennifer ; Shakeri, Ramin ; Shalnova, Svetlana A ; Shamah-Levy, Teresa ; Sharafkhah, Maryam ; Sharma, Sanjib K ; Shaw, Jonathan E ; Shayanrad, Amaneh ; Shi, Zumin ; Shibuya, Kenji ; Shimizu-Furusawa, Hana ; Shin, Dong Wook ; Shin, Youchan ; Shirani, Majid ; Shiri, Rahman ; Shrestha, Namuna ; Si-Ramlee, Khairil ; Siani, Alfonso ; Siantar, Rosalynn ; Sibai, Abla M ; Santos Silva, Diego Augusto ; Simon, Mary ; Simons, Judith ; Simons, Leon A ; Sjostrom, Michael ; Skaaby, Tea ; Slowikowska-Hilczer, Jolanta ; Slusarczyk, Przemyslaw ; Smeeth, Liam ; Snijder, Marieke B ; Soderberg, Stefan ; Soemantri, Agustinus ; Sofat, Reecha ; Solfrizzi, Vincenzo ; Somi, Mohammad Hossein ; Sonestedt, Emily ; Sorensen, Thorkild IA ; Jerome, Charles Sossa ; Soumare, Aicha ; Sozmen, Kaan ; Sparrenberger, Karen ; Staessen, Jan A ; Stathopoulou, Maria G ; Stavreski, Bill ; Steene-Johannessen, Jostein ; Stehle, Peter ; Stein, Aryeh D ; Stessman, Jochanan ; Stevanovic, Ranko ; Stieber, Jutta ; Stockl, Doris ; Stokwiszewski, Jakub ; Stronks, Karien ; Strufaldi, Maria Wany ; Suarez-Medina, Ramon ; Sun, Chien-An ; Sundstrom, Johan ; Suriyawongpaisal, Paibul ; Sy, Rody G ; Sylva, Rene Charles ; Szklo, Moyses ; Tai, E Shyong ; Tamosiunas, Abdonas ; Tan, EngJoo ; Tarawneh, Mohammed Rasoul ; Tarqui-Mamani, Carolina B ; Taylor, Anne ; Taylor, Julie ; Tell, Grethe S ; Tello, Tania ; Thankappan, KR ; Thijs, Lutgarde ; Thuesen, Betina H ; Toft, Ulla ; Tolonen, Hanna K ; Tolstrup, Janne S ; Topbas, Murat ; Topor-Madry, Roman ; Tormo, Maria Jose ; Tornaritis, Michael J ; Torrent, Maties ; Torres-Collado, Laura ; Traissac, Pierre ; Trinh, Oanh TH ; Truthmann, Julia ; Tsugane, Shoichiro ; Tulloch-Reid, Marshall K ; Tuomainen, Tomi-Pekka ; Tuomilehto, Jaakko ; Tybjaerg-Hansen, Anne ; Tzourio, Christophe ; Ueda, Peter ; Ugel, Eunice ; Ulmer, Hanno ; Unal, Belgin ; Uusitalo, Hannu MT ; Valdivia, Gonzalo ; Valvi, Damaskini ; van Dam, RobM ; van der Schouw, Yvonne T ; Van Herck, Koen ; Hoang, Van Minh ; Rossem, Lenievan ; Van Schoor, Natasja M ; van Valkengoed, Irene GM ; Vanderschueren, Dirk ; Vanuzzo, Diego ; Varbo, Anette ; Varona-Perez, Patricia ; Vasan, Senthil K ; Vatten, Lars ; Vega, Tomas ; Veidebaum, Toomas ; Velasquez-Melendez, Gustavo ; Venero-Fernandez, Silvia J ; Veronesi, Giovanni ; MoniqueVerschuren, WM ; Victora, Cesar G ; Vidiawati, Dhanasari ; Viet, Lucie ; Villalpando, Salvador ; Vioque, Jesus ; Virtanen, Jyrki K ; Visvikis-Siest, Sophie ; Viswanathan, Bharathi ; Vlasoff, Tiina ; Vollenweider, Peter ; Voutilainen, Ari ; Wade, Alisha N ; Wagner, Aline ; Walton, Janette ; Bebakar, Wan Mohamad Wan ; WanMohamud, Wan Nazaimoon ; Wang, Ming-Dong ; Wang, Ningli ; Wang, Qian ; Wang, Ya Xing ; Wang, Ying-Wei ; Wannamethee, S Goya ; Wedderkopp, Niels ; Wei, Wenbin ; Whincup, Peter H ; Widhalm, Kurt ; Widyahening, Indah S ; Wiecek, Andrzej ; Wijga, Alet H ; Wilks, Rainford J ; Willeit, Johann ; Willeit, Peter ; Wilsgaard, Tom ; Wojtyniak, Bogdan ; Wong-McClure, Roy A ; Wong, Andrew ; Wong, Tien Yin ; Woo, Jean ; Woodward, Mark ; Wu, Frederick C ; Wu, Shouling ; Xu, Haiquan ; Xu, Liang ; Yan, Weili ; Yang, Xiaoguang ; Yasuharu, Tabara ; Ye, Xingwang ; Yeow, Toh Peng ; Yiallouros, Panayiotis K ; Yoosefi, Moein ; Yoshihara, Akihiro ; You, San-Lin ; Younger-Coleman, Novie O ; Yusoff, Ahmad Faudzi ; Zainuddin, Ahmad A ; Zakavi, Seyed Rasoul ; Zali, Mohammad Reza ; Zamani, Farhad ; Zambon, Sabina ; Zampelas, Antonis ; KoZaw, Ko ; Zdrojewski, Tomasz ; Vrkic, Tajana Zeljkovic ; Zhang, Zhen-Yu ; Zhao, Wenhua ; Zhen, Shiqi ; Zheng, Yingfeng ; Zholdin, Bekbolat ; Zhussupov, Baurzhan ; Zoghlami, Nada ; Cisneros, Julio Zuniga ; Gregg, Edward W ; Ezzati, Majid
Keywords:
Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, DENSITY-LIPOPROTEIN CHOLESTEROL, CARDIOVASCULAR RISK-FACTORS, SERUM-CHOLESTEROL, ATHEROSCLEROSIS SOCIETY, 20-YEAR TRENDS, BLOOD-PRESSURE, MEDICATION USE, HEART-DISEASE, LIPIDS, POPULATION, Adolescent, Adult, Aged, Aged, 80 and over, Bayes Theorem, Cholesterol, HDL, Cholesterol, LDL, Female, Humans, Hypercholesterolemia, Internationality, Male, Middle Aged, Myocardial Ischemia, Stroke, Triglycerides, Young Adult, NCD Risk Factor Collaboration (NCD-RisC), General Science & Technology
Abstract:
High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.