Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Cell Biology, Ca2+, mitochondrial metabolism, malate-aspartate shuttle, MCU, PHYSIOLOGICAL-ROLE, CALCIUM, Ca(2+), Animals, Aspartic Acid, Calcium, Cytosol, Humans, Malates, Mitochondria, Pyruvic Acid, 0601 Biochemistry and Cell Biology, 0606 Physiology, 1116 Medical Physiology, Biochemistry & Molecular Biology, 3101 Biochemistry and cell biology, 3208 Medical physiology

Abstract:

It is generally accepted that mitochondrial Ca2+ controls the pace of mitochondrial bioenergetics and thus ATP production. Szibor et al. challenge this paradigm, proposing that the balance between ATP consumption and production depends on mitochondrial pyruvate supply via the malate-aspartate shuttle (MAS) and is controlled by cytosolic Ca2+.