Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Oncology, Medicine, Research & Experimental, Research & Experimental Medicine, EXTRACELLULAR VESICLES, TUMOR-GROWTH, SULFATE PROTEOGLYCANS, MAMMALIAN HEPARANASE, ESCRT MACHINERY, PDZ PROTEIN, SYNTENIN, BINDING, SYNDECAN, BIOGENESIS, ALIX, ESCRT, Exosomal cargo, Heparan sulfate, Heparanase, PDZ domains, Syndecan, Syntenin, Tumor progression, Exosomes, Glucuronidase, Humans, Syndecans, Syntenins, 11 Medical and Health Sciences, General & Internal Medicine, 31 Biological sciences, 32 Biomedical and clinical sciences

Abstract:

Exosomes are secreted vesicles involved in signaling processes. The biogenesis of a class of these extracellular vesicles depends on syntenin, and on the interaction of this cytosolic protein with syndecans. Heparanase, largely an endosomal enzyme, acts as a regulator of the syndecan-syntenin-exosome biogenesis pathway. The upregulation of syntenin and heparanase in cancers may support the suspected roles of exosomes in tumor biology.