Author:

Keywords:

Social Sciences, Science & Technology, Life Sciences & Biomedicine, Education, Special, Rehabilitation, Education & Educational Research, Cerebral palsy, Magnetic resonance imaging, Motor, Systematic review, INDUCED MOVEMENT THERAPY, UPPER-LIMB FUNCTION, HAND FUNCTION, BRAIN-INJURY, CLASSIFICATION-SYSTEM, CORTICOSPINAL TRACT, PEDIATRIC-PATIENTS, YOUNG-CHILDREN, MATTER INJURY, RESTING STATE, Adolescent, Brain, Cerebral Palsy, Child, Child, Preschool, Diffusion Magnetic Resonance Imaging, Dyskinesias, Gait, Gray Matter, Humans, Infant, Leukomalacia, Periventricular, Magnetic Resonance Imaging, Muscle Spasticity, Neuroimaging, White Matter, G0C4919N#54970011, 1117 Public Health and Health Services, 1303 Specialist Studies in Education, 1701 Psychology, 3904 Specialist studies in education, 4203 Health services and systems, 5201 Applied and developmental psychology

Abstract:

BACKGROUND: Conventional Structural Magnetic Resonance Imaging (sMRI) is a mainstay in Cerebral Palsy (CP) diagnosis. AIMS: A systematic literature review was performed with the aim to investigate the relationship between structural brain lesions identified by sMRI and motor outcomes in children with CP. METHODS: Fifty-eight studies were included. The results were analysed in terms of population characteristics, sMRI (classified according to Krägeloh-Mann & Horber, 2007), gross and fine motor function and their interrelation. OUTCOMES: White matter lesions were the most common brain lesion types and were present in 57.8 % of all children with uCP, in 67.0 % of all children with bCP and in 33 % of the group of mixed subtypes. Grey matter lesions were most frequently registered in children with dyskinesia (n = 42.2 %). No structural anomalies visualized by sMRI were reported in 5.7 % of all cases. In all lesion types, an equal distribution over the different gross motor function classification system categories was present. The included studies did not report sufficient information about fine motor function to relate these results to structural imaging. CONCLUSIONS AND IMPLICATIONS: The relationship between brain structure and motor outcome needs to be further elucidated in a representative cohort of children with CP, using a more standardized MRI classification system.