Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a

Popping, Stephanie; Verwijs, Rosanne; Cuypers, Lize; Claassen, Mark A; van den Berk, Guido E; De Weggheleire, Anja; Arends, Joop E; Boerekamps, Anne; Molenkamp, Richard; Koopmans, Marion P; Verbon, Annelies; Boucher, Charles AB; Rijnders, Bart J; van de Vijver, David AMC

doi:10.1093/cid/ciaa145

Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a

Author:

Popping, Stephanie

Verwijs, Rosanne ; Cuypers, Lize ; Claassen, Mark A ; van den Berk, Guido E ; De Weggheleire, Anja ; Arends, Joop E ; Boerekamps, Anne ; Molenkamp, Richard ; Koopmans, Marion P ; Verbon, Annelies ; Boucher, Charles AB ; Rijnders, Bart J ; van de Vijver, David AMC

Keywords:

Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, Microbiology, hepatitis C virus, resistant associated substitutions, phylogenetic analysis, the WHO 2030 elimination goals, HIV co-infected MSM, INHIBITOR, POLYMORPHISM, Q80K, Antiviral Agents, Drug Resistance, Viral, Genotype, Hepacivirus, Hepatitis C, Hepatitis C, Chronic, Homosexuality, Male, Humans, Male, Phylogeny, Sexual and Gender Minorities, Viral Nonstructural Proteins, Dutch Acute HCV in HIV Study Investigators, 06 Biological Sciences, 11 Medical and Health Sciences, 3202 Clinical sciences

Abstract:

The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.