Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, Extraintestinal manifestations, Crohn's disease, ulcerative colitis, metastatic Crohn's disease, pyoderma gangrenosum, PYODERMA-GANGRENOSUM, EXTRAINTESTINAL MANIFESTATIONS, CROHNS-DISEASE, MAINTENANCE THERAPY, INDUCTION, PERINEAL, Crohn’s disease, metastatic Crohn’s disease, Adult, Antibodies, Monoclonal, Humanized, Colitis, Ulcerative, Crohn Disease, Dermatologic Agents, Duration of Therapy, Erythema Nodosum, Female, Humans, Immunologic Factors, Male, Patient Acuity, Pyoderma Gangrenosum, Remission Induction, Severity of Illness Index, Skin Diseases, Treatment Outcome, Ustekinumab, 1103 Clinical Sciences, 3202 Clinical sciences

Abstract:

This was a multicentre case series supported by the European Crohn's and Colitis Organisation [ECCO] and performed as part of the Collaborative Network of Exceptionally Rare case reports [CONFER] project. The aim was to report on whether cutaneous lesions associated with inflammatory bowel disease [IBD] and refractory to standard medical therapy including anti-tumour necrosis factors [anti-TNFs], would respond to the newer biologic agents ustekinumab [UST] or vedolizumab [VDZ]. This report includes 28 patients with cutaneous lesions from 14 centres, all of whom had failed immunomodulator and anti-TNF therapy. Metastatic Crohn's disease [MCD] was diagnosed in 10 patients: UST led to remission in five cases and partial response in four cases, with a single report of VDZ inducing remission. All cases of MCD treated with UST responded after the first or second dose, and the median time for the five cases that attained remission was 5 months. Pyoderma gangrenosum [PG] was diagnosed in four cases: three of these attained remission with UST [median time to remission 4 months] and one case did not respond to VDZ. There were seven cases of erythema nodosum [EN]: UST led to remission in four cases and partial response in 1 case whilst VDZ had partial response in 2 cases and non-response in two cases. There were seven single cases of other inflammatory lesions. In summary, UST appears to be useful for different cutaneous lesions including MCD, PG, and EN, whereas VDZ does not appear to be useful for lesions that are independent of disease activity.