Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Davies, Melanie J; D'Alessio, David A; Fradkin, Judith; Kernan, Walter N; Mathieu, Chantal; Mingrone, Geltrude; Rossing, Peter; Tsapas, Apostolos; Wexler, Deborah J; Buse, John B

doi:10.1007/s00125-018-4729-5

Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Author:

Davies, Melanie J

D'Alessio, David A ; Fradkin, Judith ; Kernan, Walter N ; Mathieu, Chantal ; Mingrone, Geltrude ; Rossing, Peter ; Tsapas, Apostolos ; Wexler, Deborah J ; Buse, John B

Keywords:

Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, Cardiovascular disease, Chronic kidney disease, Costs, Glucose-lowering therapy, Guidelines, Heart failure, Hypoglycaemia, Patient-centred care, Type 2 diabetes mellitus, Weight management, RANDOMIZED CONTROLLED-TRIAL, PEPTIDE-1 RECEPTOR AGONISTS, DIPEPTIDYL PEPTIDASE-4 INHIBITORS, COTRANSPORTER 2 INHIBITORS, CLINICAL-PRACTICE GUIDELINES, CARDIOVASCULAR RISK-FACTORS, GLARGINE PLUS LIXISENATIDE, INTENSIVE MEDICAL THERAPY, MULTIPLE DAILY INJECTIONS, FIXED-RATIO COMBINATION, Cardiovascular Diseases, Consensus, Diabetes Mellitus, Type 2, Europe, Glucagon-Like Peptide-1 Receptor, Heart Failure, Humans, Hyperglycemia, Hypoglycemic Agents, Insulin, Liraglutide, Renal Insufficiency, Chronic, Sodium-Glucose Transporter 2 Inhibitors, United States, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 1117 Public Health and Health Services, 3202 Clinical sciences, 4206 Public health

Abstract:

The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the prior position statements, published in 2012 and 2015, on the management of type 2 diabetes in adults. A systematic evaluation of the literature since 2014 informed new recommendations. These include additional focus on lifestyle management and diabetes self-management education and support. For those with obesity, efforts targeting weight loss, including lifestyle, medication and surgical interventions, are recommended. With regards to medication management, for patients with clinical cardiovascular disease, a sodium-glucose cotransporter-2 (SGLT2) inhibitor or a glucagon-like peptide-1 (GLP-1) receptor agonist with proven cardiovascular benefit is recommended. For patients with chronic kidney disease or clinical heart failure and atherosclerotic cardiovascular disease, an SGLT2 inhibitor with proven benefit is recommended. GLP-1 receptor agonists are generally recommended as the first injectable medication.