Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase

Oeckl, Patrick; Weydt, Patrick; Steinacker, Petra; Anderl-Straub, Sarah; Nordin, Frida; Volk, Alexander E; Diehl-Schmid, Janine; Andersen, Peter M; Kornhuber, Johannes; Danek, Adrian; Fassbender, Klaus; Fliessbach, Klaus; Jahn, Holger; Lauer, Martin; Mueller, Kathrin; Knehr, Antje; Prudlo, Johannes; Schneider, Anja; Thal, Dietmar R; Yilmazer-Hanke, Deniz; Weishaupt, Jochen H; Ludolph, Albert C; Otto, Markus

doi:10.1136/jnnp-2018-318868

Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase

Author:

Oeckl, Patrick

Weydt, Patrick ; Steinacker, Petra ; Anderl-Straub, Sarah ; Nordin, Frida ; Volk, Alexander E ; Diehl-Schmid, Janine ; Andersen, Peter M ; Kornhuber, Johannes ; Danek, Adrian ; Fassbender, Klaus ; Fliessbach, Klaus ; Jahn, Holger ; Lauer, Martin ; Mueller, Kathrin ; Knehr, Antje ; Prudlo, Johannes ; Schneider, Anja ; Thal, Dietmar R ; Yilmazer-Hanke, Deniz ; Weishaupt, Jochen H ; Ludolph, Albert C ; Otto, Markus

Keywords:

Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Psychiatry, Surgery, Neurosciences & Neurology, HUMAN CHITOTRIOSIDASE GENE, ALS, BIOMARKERS, PROGRESSION, PROTEIN, YKL-40, CHIT1, GFAP, amyotrophic lateral sclerosis, cerebrospinal fluid, frontotemporal dementia, neuroinflammation, Adult, Aged, Amyotrophic Lateral Sclerosis, Asymptomatic Diseases, Case-Control Studies, Chitinase-3-Like Protein 1, Female, Frontotemporal Dementia, Glial Fibrillary Acidic Protein, Heterozygote, Hexosaminidases, Humans, Male, Middle Aged, Mutation, German Consortium for Frontotemporal Lobar Degeneration, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences, Neurology & Neurosurgery, 3202 Clinical sciences, 3209 Neurosciences

Abstract:

OBJECTIVE: To investigate the role of neuroinflammation in asymptomatic and symptomatic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mutation carriers. METHODS: The neuroinflammatory markers chitotriosidase 1 (CHIT1), YKL-40 and glial fibrillary acidic protein (GFAP) were measured in cerebrospinal fluid (CSF) and blood samples from asymptomatic and symptomatic ALS/FTD mutation carriers, sporadic cases and controls by ELISA. RESULTS: CSF levels of CHIT1, YKL-40 and GFAP were unaffected in asymptomatic mutation carriers (n=16). CHIT1 and YKL-40 were increased in gALS (p<0.001, n=65) whereas GFAP was not affected. Patients with ALS carrying a CHIT1 polymorphism had lower CHIT1 concentrations in CSF (-80%) whereas this polymorphism had no influence on disease severity. In gFTD (n=23), increased YKL-40 and GFAP were observed (p<0.05), whereas CHIT1 was nearly not affected. The same profile as in gALS and gFTD was observed in sALS (n=64/70) and sFTD (n=20/26). CSF and blood concentrations correlated moderately (CHIT1, r=0.51) to weak (YKL-40, r=0.30, GFAP, r=0.39). Blood concentrations of these three markers were not significantly altered in any of the groups except CHIT1 in gALS of the Ulm cohort (p<0.05). CONCLUSION: Our data indicate that neuroinflammation is linked to the symptomatic phase of ALS/FTD and shows a similar pattern in sporadic and genetic cases. ALS and FTD are characterised by a different neuroinflammatory profile, which might be one driver of the diverse presentations of the ALS/FTD syndrome.