Identification of an Amino Acid Motif in HLA–DRβ1 That Distinguishes Uveitis in Patients With Juvenile Idiopathic Arthritis

Haasnoot, Anne-Mieke JW; Schilham, Marco W; Kamphuis, Sylvia; Hissink Muller, Petra CE; Heiligenhaus, Arnd; Foell, Dirk; Minden, Kirsten; Ophoff, Roel A; Radstake, Timothy RDJ; Den Hollander, Anneke I; Reinards, Tjitske HCM; Hiddingh, Sanne; Schalij-Delfos, Nicoline E; Hoppenreijs, Esther PAH; van Rossum, Marion AJ; Wouters, Carine; Saurenmann, Rotraud K; van den Berg, J Merlijn; Wulffraat, Nico M; Ten Cate, Rebecca; de Boer, Joke H; Pulit, Sara L; Kuiper, Jonas JW

doi:10.1002/art.40484

Identification of an Amino Acid Motif in HLA–DRβ1 That Distinguishes Uveitis in Patients With Juvenile Idiopathic Arthritis

Author:

Haasnoot, Anne-Mieke JW

Schilham, Marco W ; Kamphuis, Sylvia ; Hissink Muller, Petra CE ; Heiligenhaus, Arnd ; Foell, Dirk ; Minden, Kirsten ; Ophoff, Roel A ; Radstake, Timothy RDJ ; Den Hollander, Anneke I ; Reinards, Tjitske HCM ; Hiddingh, Sanne ; Schalij-Delfos, Nicoline E ; Hoppenreijs, Esther PAH ; van Rossum, Marion AJ ; Wouters, Carine ; Saurenmann, Rotraud K ; van den Berg, J Merlijn ; Wulffraat, Nico M ; Ten Cate, Rebecca ; de Boer, Joke H ; Pulit, Sara L ; Kuiper, Jonas JW

Keywords:

Science & Technology, Life Sciences & Biomedicine, Rheumatology, GENOME-WIDE ASSOCIATION, RHEUMATOID-ARTHRITIS, SUSCEPTIBILITY LOCUS, GENOTYPE IMPUTATION, RISK-FACTORS, CHILDREN, DISEASE, METAANALYSIS, MOLECULES, BIOMARKER, Adolescent, Alleles, Amino Acid Motifs, Arthritis, Juvenile, Child, Child, Preschool, Cohort Studies, Female, Genetic Association Studies, Genetic Loci, Genetic Predisposition to Disease, Genotype, HLA-DRB1 Chains, Humans, Male, Odds Ratio, Uveitis, ICON-JIA Study Group, 3202 Clinical sciences, 3204 Immunology

Abstract:

Uveitis is a visually-debilitating disorder that affects up to 30% of children with the most common forms of juvenile idiopathic arthritis (JIA). The disease mechanisms predisposing only a subgroup of children to uveitis are unknown. To identify genetic susceptibility loci for uveitis in JIA, we conducted a genome-wide association study totalling 522 JIA cases.