Combined in silico, in vitro and in cellulo analysis of ATP binding site kinase inhibitors shows a direct correlation between potency to inhibit LRRK2 kinase activity in vitro and potency to dephosphorylate LRRK2 at Ser935 in mammalian cell

AD/PD, Date: 2013/03/06 - 2013/03/10, Location: Florence, Italy

Publication date: 2013-03-01

Combined in silico, in vitro and in cellulo analysis of ATP binding site kinase inhibitors shows a direct correlation between potency to inhibit LRRK2 kinase activity in vitro and potency to dephosphorylate LRRK2 at Ser935 in mammalian cell

Author:

Vancraenenbroeck, Renée

Gao, Fangye ; Baekelandt, Veerle ; De Maeyer, Marc ; Taymans, Jean-Marc