Author:

Keywords:

Nutri-CARE - 321670;info:eu-repo/grantAgreement/EC/FP7/321670, Science & Technology, Life Sciences & Biomedicine, Obstetrics & Gynecology, Thyroid hormones, pregnancy, preeclampsia, hypertension, prematurity, placenta, III DEIODINASE ACTIVITY, TRANSIENT HYPOTHYROXINEMIA, IODOTHYRONINE DEIODINASE, THYROXINE, EXPRESSION, 5-DEIODINATION, ASSOCIATION, THYROTROPIN, PREGNANCY, PITUITARY, Adult, Case-Control Studies, Female, Humans, Hypothyroidism, Infant, Newborn, Male, Placenta, Pregnancy, Pregnancy Complications, Premature Birth, RNA, Messenger, Thyroid Function Tests, Thyrotropin, Thyroxine, Young Adult, 1114 Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, 3213 Paediatrics, 3215 Reproductive medicine, 4204 Midwifery

Abstract:

During pregnancy, maternal thyroid hormone supply is crucial for fetal development. Preterm infants often present with hypothyroxinemia. Preterm birth, either spontaneous or medically indicated, is always the result of a complicated pregnancy. We hypothesized that in preterm birth, the maternal transplacental thyroid hormone supply is influenced by the pregnancy complication and we questioned whether maternal and placental compensatory mechanisms are activated to increase thyroid hormone transfer.